Acifran
Tocris Bioscience, part of Bio-Techne | Catalog # 1762
Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors
Key Product Details
Description
Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors
Alternative Names
AY 25712
Product Description
Acifran is a hypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC50 values are 1.3 and 4.2 μM respectively). Reduces serum triglycerides and circulating LDL-cholesterol in vivo, without affecting liver weight or liver enzymes.Product Specifications
Molecular Weight
218.21
Formula
C12H10O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid
CAS Number
72420-38-3
PubChem ID
51576
InChI Key
DFDGRKNOFOJBAJ-UHFFFAOYSA-N
SMILES
CC1(OC(=CC1=O)C(O)=O)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.82 | 100 | |
| Ethanol | 21.82 | 100 |
Preparing Stock Solutions
for Acifran
The following data is based on the product molecular weight 218.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.58 mL | 22.91 mL | 45.83 mL |
| 5 mM | 0.92 mL | 4.58 mL | 9.17 mL |
| 10 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.92 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wise Molecular identification of high and low affinity receptors for nicotinic acid. J.Biol.Chem. 2003 PMID: 12522134
- Jirkovsky and Cayen Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids. J.Med.Chem. 1982 PMID: 7143351
- Jung Analogues of acrifan: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J.Med.Chem. 2007 PMID: 17358052
- Cayen Evaluation of the lipid-lowering activity of AY-25,712 in rats. Atherosclerosis 1982 PMID: 6818976
Product Specific Notices for Acifran
For research use only
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