Acifran

Tocris Bioscience, part of Bio-Techne | Catalog # 1762

COA / SDS

Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors

Key Product Details

Description:	Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors
Alternative Names:	AY 25712
Chemical Name:	4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	218.21

View Full Technical Details for Acifran

Technical Data
Citations

Biological Activity for Acifran

Acifran is a hypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC₅₀ values are 1.3 and 4.2 μM respectively). Reduces serum triglycerides and circulating LDL-cholesterol in vivo, without affecting liver weight or liver enzymes.

Technical Data for Acifran

M. Wt	218.21
Formula	C₁₂H₁₀O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	72420-38-3
PubChem ID	51576
InChi Key	DFDGRKNOFOJBAJ-UHFFFAOYSA-N
Smiles	CC1(OC(=CC1=O)C(O)=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Acifran

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	21.82	100
	DMSO	21.82	100

Preparing Stock Solutions for Acifran

The following data is based on the product molecular weight 218.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.58 mL	22.91 mL	45.83 mL
5 mM	0.92 mL	4.58 mL	9.17 mL
10 mM	0.46 mL	2.29 mL	4.58 mL
50 mM	0.09 mL	0.46 mL	0.92 mL

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Reconstitution Calculator

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References for Acifran

References are publications that support the biological activity of the product.

Wise Molecular identification of high and low affinity receptors for nicotinic acid. J.Biol.Chem. 2003 PMID: 12522134
Jirkovsky and Cayen Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids. J.Med.Chem. 1982 PMID: 7143351
Jung Analogues of acrifan: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J.Med.Chem. 2007 PMID: 17358052
Cayen Evaluation of the lipid-lowering activity of AY-25,712 in rats. Atherosclerosis 1982 PMID: 6818976