ACHP

Tocris Bioscience, part of Bio-Techne | Catalog # 4547

Selective IKKα and IKKβ inhibitor
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Key Product Details

Description

Selective IKKα and IKKβ inhibitor

View all IkB Kinase Inhibitors »

Product Description

ACHP is a IκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively). Selective for IKKα and IKKβ over IKK3, Syk and MAPKKK4 (IC50 values are > 20 μM). Inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis. Also inhibits STAT3 signaling in NSCLC in vitro.

Product Specifications

Molecular Weight

364.44

Formula

C21H24N4O2

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile

CAS Number

406208-42-2

PubChem ID

65663

InChI Key

SRVFFFJZQVENJC-IHRRRGAJSA-N

SMILES

OC1=CC=CC(OCC3CC3)=C1C2=NC(N)=C(C#N)C(C4CCNCC4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.29 20

Preparing Stock Solutions for ACHP

The following data is based on the product molecular weight 364.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.72 mL 68.60 mL 137.20 mL
1 mM 2.74 mL 13.72 mL 27.44 mL
2 mM 1.37 mL 6.86 mL 13.72 mL
10 mM 0.27 mL 1.37 mL 2.74 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for ACHP

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ACHP

For research use only

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