Acetyl-Calpastatin (184-210) (human)

Name: Acetyl-Calpastatin (184-210) (human)
Brand: Tocris Bioscience
SKU: 2950

Tocris Bioscience, part of Bio-Techne | Catalog # 2950

Citations (8)

COA / SDS

Selective calpain inhibitor

Discontinued Product

2950 has been discontinued. View all Calpain Inhibitors products.

Key Product Details

Description:	Selective calpain inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	3177.65

View Full Technical Details for Acetyl-Calpastatin (184-210) (human)

Technical Data
Citations

Biological Activity for Acetyl-Calpastatin (184-210) (human)

Acetyl-Calpastatin (184-210) (human) is a selective calpain inhibitor. Strongly inhibits calpain I (K_i = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (K_i = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.

Technical Data for Acetyl-Calpastatin (184-210) (human)

M. Wt	3177.65
Formula	C₁₄₂H₂₃₀N₃₆O₄₄S
Single Letter Sequence	DPMSSTYIEELGKREVTIPPKYRELLA (Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	123714-50-1
PubChem ID	90488788
InChi Key	ZXJCOYBPXOBJMU-HSQGJUDPSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Acetyl-Calpastatin (184-210) (human)

References are publications that support the biological activity of the product.

Yamazaki Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem.
Fiorino A new cell-permeable calpain inhibitor. J.Peptide Sci.
Maki Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 1989 PMID: 2553724

Acetyl-Calpastatin (184-210) (human)

Tocris Bioscience, part of Bio-Techne | Catalog # 2950

Key Product Details

Biological Activity for Acetyl-Calpastatin (184-210) (human)

Technical Data for Acetyl-Calpastatin (184-210) (human)

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Acetyl-Calpastatin (184-210) (human)

Product Documents for Acetyl-Calpastatin (184-210) (human)

COA

Certificate of Analysis

SDS

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