Acetaminophen
Tocris Bioscience, part of Bio-Techne | Catalog # 1706
Cyclooxygenase inhibitor; may be selective for COX-3
Key Product Details
Description
Cyclooxygenase inhibitor; may be selective for COX-3
Alternative Names
Paracetamol
Product Description
Acetaminophen is a cyclooxygenase inhibitor; may be selective for COX-3 (IC50 values are 460, > 1000 and > 1000 μM for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.Product Specifications
Molecular Weight
151.16
Formula
C8H9NO2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-(4-Hydroxyphenyl)acetamide
CAS Number
103-90-2
PubChem ID
1983
InChI Key
RZVAJINKPMORJF-UHFFFAOYSA-N
SMILES
CC(=O)NC1=CC=C(O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.12 | 100 | |
| Ethanol | 15.12 | 100 |
Preparing Stock Solutions
for Acetaminophen
The following data is based on the product molecular weight 151.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.62 mL | 33.08 mL | 66.16 mL |
| 5 mM | 1.32 mL | 6.62 mL | 13.23 mL |
| 10 mM | 0.66 mL | 3.31 mL | 6.62 mL |
| 50 mM | 0.13 mL | 0.66 mL | 1.32 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chong Effect of acetaminophen on atherosclerosis. Ann.Pharmacother. 2001 PMID: 11724102
- Riendeau Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDS) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can.J.Physiol.Pharmacol. 1997 PMID: 9365818
- Chandrasekharan COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc.Natl.Acad.Sci.U.S.A. 2002 PMID: 12242329
Product Specific Notices for Acetaminophen
For research use only
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