ACET
Tocris Bioscience, part of Bio-Techne | Catalog # 2728
Potent kainate antagonist; displays selectivity for GluK1-containing receptors
Key Product Details
Description
Potent kainate antagonist; displays selectivity for GluK1-containing receptors
Product Description
ACET is a potent and selective GluK1 (formerly GluR5) containing kainate receptor antagonist (IC50 = 7 nM) that displays selectivity over GluK2 (formerly GluR6) containing kainate, NMDA, AMPA and group I mGlu receptors. Reversibly blocks induction of NMDA receptor-independent long term potentiation (LTP) in vitro at nanomolar concentrations.Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Product Specifications
Molecular Weight
429.45
Formula
C20H19N3O6S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-5-phenylthiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
CAS Number
936095-50-0
PubChem ID
16125102
InChI Key
LCZDCKMQSBGXAH-AWEZNQCLSA-N
SMILES
O=C(C(C)=CN1C[C@@H](C(O)=O)N)N(CC2=C(C(O)=O)SC(C3=CC=CC=C3)=C2)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 3eq. NaOH | 4.29 | 10 | |
| DMSO | 8.59 | 20 |
Preparing Stock Solutions
for ACET
The following data is based on the product molecular weight 429.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.64 mL | 58.21 mL | 116.43 mL |
| 1 mM | 2.33 mL | 11.64 mL | 23.29 mL |
| 2 mM | 1.16 mL | 5.82 mL | 11.64 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dargan ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function. Neuropharmacology 2009 PMID: 18789344
- Dolman Synthesis and pharmacological characterisation of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonis J.Med.Chem. 2007 PMID: 17348638
Product Specific Notices for ACET
For research use only
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