AC 55649
Tocris Bioscience, part of Bio-Techne | Catalog # 2436
Selective RARβ2 agonist
Discontinued Product
2436 has been discontinued.
View all Retinoic Acid Receptor Agonists products.
Product Description
AC 55649 is a potent, isoform-selective RARβ2 receptor agonist (pEC50 values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARα respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.Product Specifications
Molecular Weight
310.44
Formula
C21H26O2
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
4'-Octyl-[1,1'-biphenyl]-4-carboxylic acid
CAS Number
59662-49-6
PubChem ID
1714884
InChI Key
HXBKPYIEQLLNBK-UHFFFAOYSA-N
SMILES
CCCCCCCCC1=CC=C(C=C1)C1=CC=C(C=C1)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.04 | 100 | |
| Ethanol | 7.76 | 25 |
Preparing Stock Solutions
for AC 55649
The following data is based on the product molecular weight 310.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.22 mL | 16.11 mL | 32.21 mL |
| 5 mM | 0.64 mL | 3.22 mL | 6.44 mL |
| 10 mM | 0.32 mL | 1.61 mL | 3.22 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lund Design, synthesis, and structure-activity analysis of isoform selective retinoic acid receptor ligands. J.Med.Chem. 2009 PMID: 19239230
- Lund Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem. 2005 PMID: 16302793
Product Specific Notices for AC 55649
For research use only
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