AC 264613
Tocris Bioscience, part of Bio-Techne | Catalog # 3370
PAR2 receptor agonist
Key Product Details
Description
PAR2 receptor agonist
Product Description
AC 264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. Stimulates PI hydrolysis, Ca2+ mobilization and cellular proliferation in vitro (pEC50 values are 6.9, 7.0 and 7.5 respectively).Product Specifications
Molecular Weight
400.27
Formula
C19H18BrN3O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide
CAS Number
1051487-82-1
PubChem ID
25108278
InChI Key
RQKXQCSEZPQBNZ-QSBCOWLBSA-N
SMILES
O=C1[C@@H]([C@](N/N=C(C)/C3=CC=CC(Br)=C3)=O)[C@H]([C@]2=CC=CC=C2)CN1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.03 | 100 |
Preparing Stock Solutions
for AC 264613
The following data is based on the product molecular weight 400.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.49 mL | 24.98 mL |
| 5 mM | 0.50 mL | 2.50 mL | 5.00 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Seitzberg Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem. 2008 PMID: 18720984
- Gardell Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther. 2008 PMID: 18768780
Product Specific Notices for AC 264613
For research use only
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