ABT 702 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2372
Adenosine kinase inhibitor; orally active
Key Product Details
Description
Adenosine kinase inhibitor; orally active
Product Description
ABT 702 hydrochloride is a potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.Product Specifications
Molecular Weight
499.79
Formula
C22H19N6OBr.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-(3-Bromophenyl)-7-[6-(4-morpholinyl)-3-pyrido[2,3-d]byrimidin-4-amine hydrochloride
CAS Number
2624336-92-9
PubChem ID
16760265
InChI Key
KXHYOZCVILMBFV-UHFFFAOYSA-N
SMILES
NC1=C2C(N=C(C3=CN=C(N4CCOCC4)C=C3)C=C2C5=CC(Br)=CC=C5)=NC=N1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.66 | 100 |
Preparing Stock Solutions
for ABT 702 hydrochloride
The following data is based on the product molecular weight 499.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.00 mL | 10.00 mL | 20.01 mL |
| 5 mM | 0.40 mL | 2.00 mL | 4.00 mL |
| 10 mM | 0.20 mL | 1.00 mL | 2.00 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kowaluk ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties II. In vivo characterization in the rat. J.Pharmacol.Exp.Ther. 2000 PMID: 11082454
- Lee Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J.Med.Chem. 2001 PMID: 11405650
- Jarvis ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I In vitro characterization and acute antinociceptive J.Pharmacol.Exp.Ther. 2000 PMID: 11082453
Product Specific Notices for ABT 702 hydrochloride
For research use only
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