Abiraterone acetate
Tocris Bioscience, part of Bio-Techne | Catalog # 6520
Potent CYP17A1 inhibitor
Product Description
Abiraterone acetate is a potent CYP17A1 inhibitor (IC50 values are 17 nM and 18 nM for 17,20-lyase activity and 17α-hydroxylase activity, respectively). Inhibits intratumor androgen synthesis in prostate cancer.Product Specifications
Molecular Weight
391.55
Formula
C26H33NO2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-yl acetate
CAS Number
154229-18-2
PubChem ID
9821849
InChI Key
UVIQSJCZCSLXRZ-UBUQANBQSA-N
SMILES
[H][C@@]12CC=C([C@]1(CC[C@]3([C@]2(CC=C4C[C@@H](OC(C)=O)CC[C@]34C)[H])[H])C)C5=CN=CC=C5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.83 | 20 | |
| Ethanol | 39.16 | 100 |
Preparing Stock Solutions
for Abiraterone acetate
The following data is based on the product molecular weight 391.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.77 mL | 25.54 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.11 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Barrie Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase). J.Steroid Biochem.Mol.Biol. 1994 PMID: 7918112
- Potter Novel steroidal inhibitors of human cytochrome P45017α (l7α-Hydroxylase-Cl7,20-lyase): potential agents for the treatment of prostatic cancer. J.Med.Chem. 1995 PMID: 7608911
Product Specific Notices for Abiraterone acetate
For research use only
⚠ WARNING: This product can expose you to chemicals including Abiraterone acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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