AA 147
Tocris Bioscience, part of Bio-Techne | Catalog # 6759
ER proteostasis regulator
Product Description
AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM).Product Specifications
Molecular Weight
255.31
Formula
C16H17NO2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-Hydroxy-5-methylphenyl)benzenepropanamide
CAS Number
393121-74-9
PubChem ID
882909
InChI Key
AWHLTHOHBAGPMY-UHFFFAOYSA-N
SMILES
CC1=CC(NC(CCC2=CC=CC=C2)=O)=C(C=C1)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.53 | 100 | |
| Ethanol | 25.53 | 100 |
Preparing Stock Solutions
for AA 147
The following data is based on the product molecular weight 255.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.92 mL | 19.58 mL | 39.17 mL |
| 5 mM | 0.78 mL | 3.92 mL | 7.83 mL |
| 10 mM | 0.39 mL | 1.96 mL | 3.92 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Plate Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife 2016 PMID: 27435961
Product Specific Notices for AA 147
For research use only
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