A37
Tocris Bioscience, part of Bio-Techne | Catalog # 5802
ALDH1A1 inhibitor
Key Product Details
Description
ALDH1A1 inhibitor
Alternative Names
CM 037
Product Description
A37 is an ALDH1A1 inhibitor (IC50 = 4.6 μM; Ki = 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro.Product Specifications
Molecular Weight
431.57
Formula
C21H25N3O3S2
Storage
Store at +4°C
Purity
≥97% (HPLC)
Chemical Name
Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrrolidinyl)propyl][1]benzothieno[3,2-d]pyrimidin-2-yl]thio]acetate
CAS Number
896795-60-1
PubChem ID
5049161
InChI Key
SKDRHRAYBYQVNU-UHFFFAOYSA-N
SMILES
O=C1N(CCCN2CCCC2)C(SCC(OCC)=O)=NC3=C1SC4=C3C=CC=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.16 | 100 | |
| Ethanol | 43.16 | 100 |
Preparing Stock Solutions
for A37
The following data is based on the product molecular weight 431.57
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.59 mL | 23.17 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Condello β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene 2015 PMID: 24954508
- Morgan and Hurley Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. J.Med.Chem 2015 PMID: 25634381
Product Specific Notices for A37
For research use only
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