α-Conotoxin MII

Name: α-Conotoxin MII
Brand: Tocris Bioscience
SKU: 1340

Tocris Bioscience, part of Bio-Techne | Catalog # 1340

Citations (6)

COA / SDS

Potent and selective α3β2 and β3 nAChR antagonist

Discontinued Product

1340 has been discontinued. View all Additional Nicotinic Receptor Antagonists products.

Key Product Details

Description:	Potent and selective α3β2 and β3 nAChR antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1710.99

View Full Technical Details for α-Conotoxin MII

Technical Data
Citations

Biological Activity for α-Conotoxin MII

α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC₅₀ = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4.

Licensing Information

Sold under license from the University of Utah.

Technical Data for α-Conotoxin MII

M. Wt	1710.99
Formula	C₆₇H₁₀₃N₂₃O₂₂S₄
Single Letter Sequence	GCCSNPVCHLEHSNLC (Modifications: Disulfide bridges: 2-8, 3-16, Cys-16 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	175735-93-0
PubChem ID	57340508
InChi Key	DUQYFGMBLOPGBY-XCQLYXDWSA-N
Smiles	[H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC2=O)C(N)=O)NC1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for α-Conotoxin MII

References are publications that support the biological activity of the product.

David Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes. Eur.J.Neurosci. 2010 PMID: 20377613
Harvey Determinants of specificity for α-conotoxin MII on α3β2 neuronal nicotinic receptors. Mol.Pharmacol. 1997 PMID: 9203640
McIntosh Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function. Eur.J.Pharmacol. 2000 PMID: 10771014
Cartier A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors. J.Biol.Chem. 1996 PMID: 8631783