A 779
Tocris Bioscience, part of Bio-Techne | Catalog # 5937
Selective Mas receptor (Ang-(1-7) receptor) antagonist
Key Product Details
Description
Selective Mas receptor (Ang-(1-7) receptor) antagonist
Product Description
A 779 is a selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.Product Specifications
Molecular Weight
872.98
Formula
C39H60N12O11
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
159432-28-7
PubChem ID
10169886
InChI Key
GZSZZUXDAPDPOR-NGIFJXEWSA-N
SMILES
[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H](C)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
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Background References
References are publications that support the biological activity of the product.
- Becker Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats. Brain Res. 2005 PMID: 15804433
- Santos Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res.Bull. 1994 PMID: 7850477
- Bruce Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. Br.J.Pharmacol. 2015 PMID: 25522140
Product Specific Notices for A 779
For research use only
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