A 71915
Tocris Bioscience, part of Bio-Techne | Catalog # 6715
Highly potent and competitive NPRA antagonist
Key Product Details
Description
Highly potent and competitive NPRA antagonist
Product Description
A 71915 is a highly potent and competitive natriuretic peptide receptor A (NPRA) antagonist (pKi = 9.18). Reduces brain natriuretic peptide (BNP, Cat. No. 3522)-induced scratching in mice.Product Specifications
Molecular Weight
1613.95
Formula
C69H116N26O15S2
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
132956-87-7
PubChem ID
25083020
InChI Key
TZQXLCWSYQJGKV-YGLLJKSHSA-N
SMILES
CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CC2CCCCC2)NC(=O)[C@H](CSS[C@H](CCCN=C(N)N)[C@H](NC(=O)CNC(=O)[C@H]2CC3=CC=CC=C3CN2C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)CC)C(N)=O)NC(=O)[C@@H](N)CCCN=C(N)N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
Molarity Calculator
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Background References
References are publications that support the biological activity of the product.
- Moro Functional and pharmacological characterization of the natriuretic peptide-dependent lipolytic pathway in human fat cells. J.Pharmacol.Exp.Ther. 2004 PMID: 14634036
- Kiguchi Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice. J.Pharmacol.Exp.Ther. 2016 PMID: 26669425
- Delporte Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur.J.Pharmacol. 1992 PMID: 1334838
Product Specific Notices for A 71915
For research use only
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