A 61603 hydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 1052
α1A agonist
Product Description
A 61603 hydrobromide is a potent α-adrenoceptor agonist that is at least 35-fold more potent at α1A than at α1B or α1D sites. Induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro (EC50 = 6.9 nmol/L).Product Specifications
Molecular Weight
390.29
Formula
C14H19N3O3S.HBr
Storage
Desiccate at +4°C
Chemical Name
N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide
CAS Number
107756-30-9
PubChem ID
9865178
InChI Key
LRFLWCZMTGTUEP-UHFFFAOYSA-N
SMILES
Br.CS(=O)(=O)NC1=C(O)C=CC2=C1CCCC2C1=NCCN1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 50 |
Preparing Stock Solutions
for A 61603 hydrobromide
The following data is based on the product molecular weight 390.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.12 mL | 25.62 mL | 51.24 mL |
| 2.5 mM | 1.02 mL | 5.12 mL | 10.25 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.12 mL |
| 25 mM | 0.10 mL | 0.51 mL | 1.02 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Luo Receptor subtype involved in α1A-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes. Acta.Pharmacol.Sin. 2007 PMID: 17588332
- Meyer Synthesis and in vitro characterisation of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α1A receptor agonist. J.Med.Chem. 1996 PMID: 8831777
- Knepper A-61603, a potent α1-adrenergic receptor agonist, selective for the α1A receptor subtype. J.Pharmacol.Exp.Ther. 1995 PMID: 7616455
Product Specific Notices for A 61603 hydrobromide
For research use only
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