A 412997 dihydrochloride

Name: A 412997 dihydrochloride
Brand: Tocris Bioscience
SKU: 4552

Tocris Bioscience, part of Bio-Techne | Catalog # 4552

Citations (3)

COA / SDS

Selective D4 agonist

Key Product Details

Description:	Selective D₄ agonist
Chemical Name:	N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	382.33

View Full Technical Details for A 412997 dihydrochloride

Technical Data
Citations

Biological Activity for A 412997 dihydrochloride

A 412997 dihydrochloride is a selective agonist for the dopamine D₄ receptor (K_i values are 7.9 and 12.1 nM for human D₄ and rat D₄ receptors). Displays no affinity (<1000 nM) for other dopamine receptors. Shows efficacy in rat models of ADHD and short-term memory.

Compound Libraries for A 412997 dihydrochloride

A 412997 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 412997 dihydrochloride

M. Wt	382.33
Formula	C₁₉H₂₃N₃O.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1347744-96-0
PubChem ID	90488953
InChi Key	KIGNSSHMCNBHQX-UHFFFAOYSA-N
Smiles	O=C(CN2CCC(C3=CC=CC=N3)CC2)NC1=CC=CC(C)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 412997 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	38.23	100
	DMSO	19.12	50

Preparing Stock Solutions for A 412997 dihydrochloride

The following data is based on the product molecular weight 382.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.62 mL	13.08 mL	26.16 mL
5 mM	0.52 mL	2.62 mL	5.23 mL
10 mM	0.26 mL	1.31 mL	2.62 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for A 412997 dihydrochloride

References are publications that support the biological activity of the product.

Patel Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable DA D₄ agonist for the treatment of erectile dysfunction. J.Med.Chem. 2006 PMID: 17149874
Moreland A-412997 is a selective DA D₄ receptor agonist in rats. Pharmacol.Biochem.Behav. 2005 PMID: 16153699
Browman A-412997, a selective DA D₄ agonist, improves cognitive performance in rats. Pharmacol.Biochem.Behav. 2005 PMID: 16154186