A 410099.1 amide-PEG5-amine
Tocris Bioscience, part of Bio-Techne | Catalog # 7221
IAP ligand with PEG linker and terminal amine for onward chemistry
Key Product Details
Description
IAP ligand with PEG linker and terminal amine for onward chemistry
Product Description
A 410099.1 amide-PEG5-amine is a functionalized IAP ligand for PROTAC® research and development; incorporates an IAP ligand plus an amide-PEG5 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
861.09
Formula
C44H72N6O11
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
tert-Butyl ((S)-1-(((S)-2-((2S,4S)-4-(17-amino-3,6,9,12,15-pentaoxaheptadecanamido)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
CAS Number
2446474-11-7
InChI Key
WUQFDZYWJGAVJW-XQVCTUMGSA-N
SMILES
CN(C(OC(C)(C)C)=O)[C@H](C(N[C@H](C(N1C[C@@H](NC(COCCOCCOCCOCCOCCN)=O)C[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)=O)C4CCCCC4)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tinworth PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding. ACS Chem.Biol. 2019 PMID: 30807093
Product Specific Notices for A 410099.1 amide-PEG5-amine
For research use only
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