A 331440 dihydrochloride

Name: A 331440 dihydrochloride
Brand: Tocris Bioscience
SKU: 4697

Tocris Bioscience, part of Bio-Techne | Catalog # 4697

COA / SDS

Selective H3 antagonist

Discontinued Product

4697 has been discontinued. View all Histamine H3 Receptor Antagonists products.

Key Product Details

Description:	Selective H₃ antagonist
Chemical Name:	4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	422.39

View Full Technical Details for A 331440 dihydrochloride

Technical Data
Citations

Biological Activity for A 331440 dihydrochloride

A 331440 dihydrochloride is a high affinity histamine H₃ receptor antagonist (K_i values are 21.7 and 22.7 nM for rat and human H₃ receptors, respectively). Exhibits selectivity for human H₃ over H₁, H₂ and H₄ receptors (K_i values are 2940, 14400 and >10000 nM respectively). Shown to reduce weight in a diet-induced obesity model.

Technical Data for A 331440 dihydrochloride

M. Wt	422.39
Formula	C₂₂H₂₇N₃O.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1049740-32-0
PubChem ID	16078942
InChi Key	XFPYVTSGYYMTFS-GHVWMZMZSA-N
Smiles	CN(C)[C@H](CC3)CN3CCCOC1=CC=C(C2=CC=C(C#N)C=C2)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for A 331440 dihydrochloride

References are publications that support the biological activity of the product.

Hancock In vitro optimization of structure activity relationships by analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H₃ receptor antagonists. Basic Clin.Pharmacol.Toxicol. 2004 PMID: 15447739
Hancock Antiobesity effects of A-331440, a novel non-imidazole histamine H₃ receptor antagonist. Eur.J.Pharmacol. 2004 PMID: 15033391

A 331440 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4697

Key Product Details

Biological Activity for A 331440 dihydrochloride

Technical Data for A 331440 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for A 331440 dihydrochloride

Product Documents for A 331440 dihydrochloride

COA

Certificate of Analysis

SDS

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