8-(3-Chlorostyryl)caffeine

Name: 8-(3-Chlorostyryl)caffeine
Brand: Tocris Bioscience
SKU: 3306

Tocris Bioscience, part of Bio-Techne | Catalog # 3306

Citations (20)

COA / SDS

Selective A2A antagonist. Also MAO-B inhibitor

Discontinued Product

3306 has been discontinued. View all Adenosine A2a Receptor Antagonists products.

Key Product Details

Description:	Selective A_2A antagonist. Also MAO-B inhibitor
Alternative Names:	CSC
Chemical Name:	(E)-8-[2-(3-Chlorophenyl)ethenyl]-3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Purity:	≥99% (HPLC)
Molecular Weight:	330.77

View Full Technical Details for 8-(3-Chlorostyryl)caffeine

Technical Data
Citations

Biological Activity for 8-(3-Chlorostyryl)caffeine

8-(3-Chlorostyryl)caffeine is a selective adenosine A_2A receptor antagonist and monoamine oxidase B (MAO-B) inhibitor (K_i values are 54 and 28200 nM at rat A_2A and A₁ receptors respectively and K_i ~ 100 nM at MAO-B). Potently protects against quinolinic acid-induced (Cat. No. 0225) neuronal damage and is neuroprotective in the MPTP model of Parkinson's disease.

Technical Data for 8-(3-Chlorostyryl)caffeine

M. Wt	330.77
Formula	C₁₆H₁₅ClN₄O₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	147700-11-6
PubChem ID	5353365
InChi Key	WBWFIUAVMCNYPG-BQYQJAHWSA-N
Smiles	ClC1=CC(/C=C/C(N3C)=NC2=C3C(N(C)C(N2C)=O)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for 8-(3-Chlorostyryl)caffeine

References are publications that support the biological activity of the product.

Behan and Stone Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A_2A receptor antagonists. Br.J.Pharmacol. 2002 PMID: 11906956
Vlok Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC). Bioorg.Med.Chem. 2006 PMID: 16442801
Chen 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions on monoamine oxidase inhibition and A_2A receptor antagonism. J.Biol.Chem. 2002 PMID: 12130655

8-(3-Chlorostyryl)caffeine

Tocris Bioscience, part of Bio-Techne | Catalog # 3306

Key Product Details

Biological Activity for 8-(3-Chlorostyryl)caffeine

Technical Data for 8-(3-Chlorostyryl)caffeine

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for 8-(3-Chlorostyryl)caffeine

Product Documents for 8-(3-Chlorostyryl)caffeine

COA

Certificate of Analysis

SDS

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