6bK
Tocris Bioscience, part of Bio-Techne | Catalog # 5402
Insulin degrading enzyme (IDE) inhibitor
Key Product Details
Description
Insulin degrading enzyme (IDE) inhibitor
Product Description
6bK is an insulin degrading enzyme (IDE) inhibitor (IC50 = 50 nM); regulates insulin, glucagon and amylin levels, and improves glucose tolerance in a diabetic mouse model.This compound is supplied in net weight as the TFA salt.
Licensing Information
Sold for research purpose under license from Harvard UniversityProduct Specifications
Molecular Weight
757.92
Formula
C41H55N7O7
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide
CAS Number
1417537-93-9
PubChem ID
91758793
InChI Key
BHZABWWULWHRIY-JAXGQCOVSA-N
SMILES
NC([C@@H](NC(/C=C/C(N[C@@H](CCCCN)C(N[C@H](C(N3)=O)CC2CCCCC2)=O)=O)=O)CCCCNC([C@H]3CC1=CC=C(C(C4=CC=CC=C4)=O)C=C1)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1 |
Preparing Stock Solutions
for 6bK
The following data is based on the product molecular weight 757.92
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.02 mM | 65.97 mL | 329.85 mL | 659.70 mL |
| 0.1 mM | 13.19 mL | 65.97 mL | 131.94 mL |
| 0.2 mM | 6.60 mL | 32.99 mL | 65.97 mL |
| 1 mM | 1.32 mL | 6.60 mL | 13.19 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Maianti Anti-diabetic activity of Ins-degrading enzyme inhibitors mediated by multiple hormones. Nature 2014 PMID: 24847884
Product Specific Notices for 6bK
For research use only
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