6877002
Tocris Bioscience, part of Bio-Techne | Catalog # 5602
CD40-TRAF6 interaction inhibitor
Key Product Details
Description
CD40-TRAF6 interaction inhibitor
Product Description
6877002 is a CD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β and IL-6 expression in macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.Product Specifications
Molecular Weight
251.32
Formula
C17H17NO
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
CAS Number
433249-94-6
PubChem ID
2291556
InChI Key
SARYOFMRLSHZFE-ZHACJKMWSA-N
SMILES
CC1=CC=C(C)C(N/C=C/C(C2=CC=CC=C2)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.13 | 100 | |
| Ethanol | 25.13 | 100 |
Preparing Stock Solutions
for 6877002
The following data is based on the product molecular weight 251.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.98 mL | 19.89 mL | 39.79 mL |
| 5 mM | 0.80 mL | 3.98 mL | 7.96 mL |
| 10 mM | 0.40 mL | 1.99 mL | 3.98 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chatzigeorgiou Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated Ins resistance. Proc.Natl.Acad.Sci.U.S.A. 2014 PMID: 24492375
Product Specific Notices for 6877002
For research use only
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