6877002

Tocris Bioscience, part of Bio-Techne | Catalog # 5602

COA / SDS

CD40-TRAF6 interaction inhibitor

Key Product Details

Description:	CD40-TRAF6 interaction inhibitor
Chemical Name:	3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	251.32

View Full Technical Details for 6877002

Technical Data
Citations

Biological Activity for 6877002

6877002 is a CD40-TRAF6 interaction inhibitor. Suppresses CD40-induced IL-1β and IL-6 expression in macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in diet-induced obese mice.

Technical Data for 6877002

M. Wt	251.32
Formula	C₁₇H₁₇NO
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	433249-94-6
PubChem ID	2291556
InChi Key	SARYOFMRLSHZFE-ZHACJKMWSA-N
Smiles	CC1=CC=C(C)C(N/C=C/C(C2=CC=CC=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 6877002

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	25.13	100
	ethanol	25.13	100

Preparing Stock Solutions for 6877002

The following data is based on the product molecular weight 251.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.98 mL	19.89 mL	39.79 mL
5 mM	0.80 mL	3.98 mL	7.96 mL
10 mM	0.40 mL	1.99 mL	3.98 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

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Reconstitution Calculator

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References for 6877002

References are publications that support the biological activity of the product.

Chatzigeorgiou Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated Ins resistance. Proc.Natl.Acad.Sci.U.S.A. 2014 PMID: 24492375