673 A

Name: 673 A
Brand: Tocris Bioscience
SKU: 6934

Tocris Bioscience, part of Bio-Techne | Catalog # 6934

Citations (2)

COA / SDS

ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC)

Discontinued Product

6934 has been discontinued. View all Aldehyde Dehydrogenase Inhibitors products.

Key Product Details

Description:	ALDH1A inhibitor; depletes CD133⁺ cancer stem cells (CSC)
Chemical Name:	4-(1,3-Dihydro-2H-isoindol-2-yl)benzaldehyde
Purity:	≥98% (HPLC)
Molecular Weight:	223.28

View Full Technical Details for 673 A

Technical Data
Citations

Biological Activity for 673 A

673 A is an aldehyde dehydrogenase (ALDH1A) inhibitor (IC₅₀ values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively). Exhibits >40-fold selectivity for ALD1A over ALDH2. Depletes CD133⁺ cancer stem cells (CSC) in ovarian cancer cell lines. Triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). Overcomes chemotherapy resistance in vivo.

Technical Data for 673 A

M. Wt	223.28
Formula	C₁₅H₁₃NO
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	109437-62-9
PubChem ID	969428
InChi Key	GSAVXYHVHQTGEA-UHFFFAOYSA-N
Smiles	O=CC1=CC=C(N2CC3=C(C=CC=C3)C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for 673 A

References are publications that support the biological activity of the product.

Raghavan Personalized medicine-based approach to model patterns of chemoresistance and tumor recurrence using ovarian cancer stem cell spheroids. Clin.Cancer Res. 2017 PMID: 28814433
Chefetz A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 2019 PMID: 30865894

673 A

Tocris Bioscience, part of Bio-Techne | Catalog # 6934

Key Product Details

Biological Activity for 673 A

Technical Data for 673 A

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for 673 A

Product Documents for 673 A

COA

Certificate of Analysis

SDS

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