6-Thioguanine

Name: 6-Thioguanine
Brand: Tocris Bioscience
SKU: 4061
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4061

(1)

Citations (3)

COA / SDS

Anticancer and immunosuppressive agent

Discontinued Product

4061 has been discontinued. View all Immunosuppressants products.

Key Product Details

Description:	Anticancer and immunosuppressive agent
Alternative Names:	6-TG
Chemical Name:	2-Amino-6-mercaptopurine
Purity:	≥98% (HPLC)
Molecular Weight:	167.19

View Full Technical Details for 6-Thioguanine

Technical Data
Citations / Reviews (1)

Biological Activity for 6-Thioguanine

6-Thioguanine is an anticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model. Also facilitates proteasome-mediated degradation of DNA (cytosine-5)-methyltransferase 1 (DNMT1). Also inhibits SARS-CoV papain-like protease (PL^pro; IC₅₀ = 5 μM for PL^pro deubiquitination activity).

Technical Data for 6-Thioguanine

M. Wt	167.19
Formula	C₅H₅N₅S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	154-42-7
PubChem ID	2723601
InChi Key	WYWHKKSPHMUBEB-UHFFFAOYSA-N
Smiles	NC1=NC(S)=C2C(NC=N2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for 6-Thioguanine

References are publications that support the biological activity of the product.

Issaeva 6-Thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. Cancer Res. 2010 PMID: 20631063
Yuan 6-thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1. Cancer Res. 2011 PMID: 21239472
Wang and Wang 6-Thioguanine perturbs cytosine methylation at CgP dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry 2009 PMID: 19236003

Product Documents for 6-Thioguanine

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Thioguanine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov