6-Hydroxydopamine hydrobromide is a selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.

Product Specifications

Molecular Weight

250.09

Formula

C₈H₁₁NO₃.HBr

Storage

Store at -20°C

Chemical Name

5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide

CAS Number

636-00-0

PubChem ID

176170

InChI Key

MLACDGUOKDOLGC-UHFFFAOYSA-N

SMILES

NCCC1=CC(O)=C(O)C=C1O.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	25.01	100
	DMSO	25.01	100

Preparing Stock Solutions for 6-Hydroxydopamine hydrobromide

The following data is based on the product molecular weight 250.09

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.00 mL	19.99 mL	39.99 mL
5 mM	0.80 mL	4.00 mL	8.00 mL
10 mM	0.40 mL	2.00 mL	4.00 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

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Background References

References are publications that support the biological activity of the product.

Soto-Otero Autoxidation and neurotoxicity of 6-hydroxyDA in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J.Neurochem. 2000 PMID: 10737618
Fujita Cell-permeable cAMP analog suppresses 6-hydroxyDA-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 PMID: 16945353
Breese and Traylor Effect of 6-hydroxyDA on brain NE and DA: evidence for selective degeneration of catecholamine neurons. J.Pharmacol.Exp.Ther. 1970 PMID: 5456173

6-Hydroxydopamine hydrobromide

Tocris Bioscience, part of Bio-Techne | Catalog # 2547

Key Product Details

Description

Alternative Names

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Product Description