5J 4
Tocris Bioscience, part of Bio-Techne | Catalog # 5490
CRAC channel blocker; anti-inflammatory
Key Product Details
Description
CRAC channel blocker; anti-inflammatory
Product Description
5J 4 is a calcium release-activated calcium (CRAC) channel blocker. Blocks store-operated calcium entry (SOCE) in HeLa-O+S cells and Th17 cells in vitro. Ameliorates symptoms and reduces CNS infiltration by mononuclear cells in a mouse model of experimental autoimmune encephalomyelitis (EAE) in vivo.Product Specifications
Molecular Weight
312.34
Formula
C16H12N2O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide
CAS Number
827001-82-1
PubChem ID
2968289
InChI Key
WMUSJLJASFXGHN-UHFFFAOYSA-N
SMILES
OC1=CC2=C(C=C1)C(NC(NC(C3=CC=CO3)=O)=S)=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.23 | 100 | |
| Ethanol | 3.12 | 10 |
Preparing Stock Solutions
for 5J 4
The following data is based on the product molecular weight 312.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.20 mL | 16.01 mL | 32.02 mL |
| 5 mM | 0.64 mL | 3.20 mL | 6.40 mL |
| 10 mM | 0.32 mL | 1.60 mL | 3.20 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kim Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J.Immunol. 2014 PMID: 24307733
Product Specific Notices for 5J 4
For research use only
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