4-IPP
Tocris Bioscience, part of Bio-Techne | Catalog # 3429
Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
Key Product Details
Description
Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
Product Description
4-IPP is an inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.Product Specifications
Molecular Weight
282.08
Formula
C10H7IN2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-Iodo-6-phenylpyrimidine
CAS Number
41270-96-6
PubChem ID
817368
InChI Key
ZTCJXHNJVLUUMR-UHFFFAOYSA-N
SMILES
IC1=NC=NC(C2=CC=CC=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.21 | 100 | |
| Ethanol | 14.1 | 50 |
Preparing Stock Solutions
for 4-IPP
The following data is based on the product molecular weight 282.08
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.55 mL | 17.73 mL | 35.45 mL |
| 5 mM | 0.71 mL | 3.55 mL | 7.09 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.55 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Winner A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res. 2008 PMID: 18794110
Product Specific Notices for 4-IPP
For research use only
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