4-Aminopyridine

Name: 4-Aminopyridine
Brand: Tocris Bioscience
SKU: 0940
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0940

(2)

Citations (267)

COA / SDS

Non-selective KV channel blocker

Key Product Details

Description:	Non-selective K_V channel blocker
Alternative Names:	4-AP
Purity:	≥98% (HPLC)
Molecular Weight:	94.12

View Full Technical Details for 4-Aminopyridine

Technical Data
Citations / Reviews (2)

Biological Activity for 4-Aminopyridine

4-Aminopyridine is a non-selective voltage-dependent K⁺-channel blocker (IC₅₀ values are 170 and 230 μM at K_V1.1 and K_V1.2 respectively). Caged 4-AP (Cat. No. 3557) is also available.

Technical Data for 4-Aminopyridine

M. Wt	94.12
Formula	C₅H₆N₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	504-24-5
PubChem ID	1727
InChi Key	NUKYPUAOHBNCPY-UHFFFAOYSA-N
Smiles	NC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 4-Aminopyridine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	9.41	100
	water	9.41	100

Preparing Stock Solutions for 4-Aminopyridine

The following data is based on the product molecular weight 94.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	10.62 mL	53.12 mL	106.25 mL
5 mM	2.12 mL	10.62 mL	21.25 mL
10 mM	1.06 mL	5.31 mL	10.62 mL
50 mM	0.21 mL	1.06 mL	2.12 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 4-Aminopyridine

References are publications that support the biological activity of the product.

Tseng Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments. J.Pharmacol.Exp.Ther. 1999 PMID: 10411564
Smith In vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative. Clin.Exp.Pharmacol.Physiol. 2009 PMID: 19413590
Tseng Reverse use dependence of Kv4.2 blockade by 4-aminopyridine. J.Pharmacol.Exp.Ther. 1996 PMID: 8930194
Bouchard and Fedida Closed and open state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. J.Pharmacol.Exp.Ther. 1995 PMID: 7473178