4,9-Anhydrotetrodotoxin is a potent and selective Na_v1.6 channel blocker (IC₅₀ values are 7.8, 341, 988, 1260, 1270, 78500 and >30000 nM for Na_v1.6, Na_v1.3, Na_v1.4, Na_v1.2, Na_v1.7, Na_v1.5 and Na_v1.8). Derivative of tetrodotoxin (Cat. No. 1078).

Product Specifications

Molecular Weight

301.25

Formula

C₁₁H₁₅N₃O₇

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol

CAS Number

13072-89-4

PubChem ID

11243537

InChI Key

STNXQECXKDMLJK-PZKHIREQSA-N

SMILES

O[C@@]1(CO)[C@H](O2)[C@H]([C@H](O3)NC(N4[H])=N)[C@]54[C@H]3[C@@]2(O)O[C@H]1[C@H]5O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1

Preparing Stock Solutions for 4,9-Anhydrotetrodotoxin

The following data is based on the product molecular weight 301.25

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.04 mM	82.99 mL	414.94 mL	829.88 mL
0.2 mM	16.60 mL	82.99 mL	165.98 mL
0.4 mM	8.30 mL	41.49 mL	82.99 mL
2 mM	1.66 mL	8.30 mL	16.60 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Hargus Evidence for a role of Na_v1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis J.Neurophysiol 2013 PMID: 23741036
Rosker The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na_v1.6 voltage-dependent sodium channel. Am.J.Physiol.Cell Physiol. 2007 PMID: 17522141

4,9-Anhydrotetrodotoxin

Tocris Bioscience, part of Bio-Techne | Catalog # 6159

Key Product Details

Description

Alternative Names

View all Voltage-gated Sodium Channel Blockers »

Product Description