Product Description
3PO is originally reported to inhibit PFKFB3 (IC50 = 25 μM). More recent reports failed to demonstrate activity in a PFKFB3 kinase assay. Reduces glycolytic flux and suppresses glucose uptake. Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro. Attenuates vessel sprouting and tumor growth in vivo. Amplifies the antiangiogenic effect of VEGFR blockade.Product Specifications
Molecular Weight
210.23
Formula
C13H10N2O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
CAS Number
13309-08-5
PubChem ID
5720233
InChI Key
UOWGYMNWMDNSTL-ONEGZZNKSA-N
SMILES
O=C(/C=C/C2=CN=CC=C2)C1=CC=NC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.02 | 100 |
Preparing Stock Solutions
for 3PO
The following data is based on the product molecular weight 210.23
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.76 mL | 23.78 mL | 47.57 mL |
| 5 mM | 0.95 mL | 4.76 mL | 9.51 mL |
| 10 mM | 0.48 mL | 2.38 mL | 4.76 mL |
| 50 mM | 0.10 mL | 0.48 mL | 0.95 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schoors Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 2014 PMID: 24332967
- Boyd Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 2015 PMID: 25849762
- Clem Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol.Cancer Ther. 2008 PMID: 18202014
Product Specific Notices for 3PO
For research use only
Loading...
Loading...