3,5-DHBA
Tocris Bioscience, part of Bio-Techne | Catalog # 4599
Selective HCA1 agonist
Product Description
3,5-DHBA is a selective agonist of hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) (EC50 ~150 μM). Inhibits lipolysis in wild-type mouse adipocytes. Displays minimal activity at HCA2 (at concentrations >10 mM) and no activity at HCA3, free fatty acid receptor (FFAR) 2 or FFAR3.Product Specifications
Molecular Weight
154.12
Formula
C7H6O4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
3,5-Dihydroxybenzoic acid
CAS Number
99-10-5
PubChem ID
7424
InChI Key
UYEMGAFJOZZIFP-UHFFFAOYSA-N
SMILES
OC1=CC(O)=CC(C(O)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 15.41 | 100 | |
| DMSO | 15.41 | 100 |
Preparing Stock Solutions
for 3,5-DHBA
The following data is based on the product molecular weight 154.12
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.49 mL | 32.44 mL | 64.88 mL |
| 5 mM | 1.30 mL | 6.49 mL | 12.98 mL |
| 10 mM | 0.65 mL | 3.24 mL | 6.49 mL |
| 50 mM | 0.13 mL | 0.65 mL | 1.30 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Liu 3,5-dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J.Pharmacol.Exp.Ther. 2012 PMID: 22434674
Product Specific Notices for 3,5-DHBA
For research use only
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