2-Phenylmelatonin
Tocris Bioscience, part of Bio-Techne | Catalog # 0680
Potent melatonin agonist
Key Product Details
Description
Potent melatonin agonist
Product Description
2-Phenylmelatonin is a highly potent melatonin agonist; displays higher affinity and greater potency than melatonin itself. The EC50 values for G protein activation in MT1 and MT2-transfected cells are 65 and 58 pM respectively.Product Specifications
Molecular Weight
308.38
Formula
C19H20N2O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(5-Methoxy-2-phenylindol-3-yl)ethyl]acetamide
CAS Number
151889-03-1
PubChem ID
4018512
InChI Key
OFCLARYYBGKCHN-UHFFFAOYSA-N
SMILES
COC1=CC=C2NC(=C(CCNC(C)=O)C2=C1)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.84 | 100 | |
| Ethanol | 30.84 | 100 |
Preparing Stock Solutions
for 2-Phenylmelatonin
The following data is based on the product molecular weight 308.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.24 mL | 16.21 mL | 32.43 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.49 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.24 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nonno Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists. Br.J.Pharmacol. 1999 PMID: 10455277
- Spadoni 2-Substituted 5-methoxy-N-acetyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity. J.Med.Chem. 1993 PMID: 8258829
- Nonno Pharmacological characterization of the human melatonin Mel1a receptor following stable transfection into NIH3T3 cells. Br.J.Pharmacol. 1998 PMID: 9647472
Product Specific Notices for 2-Phenylmelatonin
For research use only
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