2-Methylthioadenosine diphosphate trisodium salt

Name: 2-Methylthioadenosine diphosphate trisodium salt
Brand: Tocris Bioscience
SKU: 1624

Catalog # 1624 | Tocris Bioscience a Bio-Techne Brand

Citations (12)

COA / SDS

Potent agonist at P2Y1, P2Y12 and P2Y13

Key Product Details

Description:	Potent agonist at P2Y₁, P2Y₁₂ and P2Y₁₃
Alternative Names:	2-(Methylthio)adenosine 5'-diphosphate, 2-Methylthio-ADP, MeSADP
Chemical Name:	2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	539.24

View Full Technical Details for 2-Methylthioadenosine diphosphate trisodium salt

Technical Data
Citations (12) / Reviews

Biological Activity for 2-Methylthioadenosine diphosphate trisodium salt

2-Methylthioadenosine diphosphate trisodium salt is a potent purinergic agonist displaying selectivity for P2Y₁, P2Y₁₂ and P2Y₁₃ receptors (pEC₅₀ = 8.29 and 9.05 for P2Y₁ and P2Y₁₂, EC₅₀ = 19 nM for P2Y₁₃). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.

Technical Data for 2-Methylthioadenosine diphosphate trisodium salt

M. Wt	539.24
Formula	C₁₁H₁₄N₅Na₃O₁₀P₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	475193-31-8
PubChem ID	52942441
InChi Key	DYNGCIHMNWOBSU-MSQVLRTGSA-K
Smiles	O[C@@H]1[C@@H](COP(OP([O-])([O-])=O)([O-])=O)O[C@@H](N3C2=NC(SC)=NC(N)=C2N=C3)[C@@H]1O.[Na+].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Methylthioadenosine diphosphate trisodium salt

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 2-Methylthioadenosine diphosphate trisodium salt

References are publications that support the biological activity of the product.

Sak and Webb A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 2002 PMID: 11747319
Zhang P2Y₁₃: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 2002 PMID: 11961076
Macfarlane 2-Methylthioadenosine[β-³²P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 1983 PMID: 6298277

Citations for 2-Methylthioadenosine diphosphate trisodium salt (12)

Showing 1 - 10 of 12 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for 2-Methylthioadenosine diphosphate trisodium salt include:

Zhang et al. (2019) P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development. Front Cell Neurosci. 13:152
PMID: 31068791
Hilt et al. (2019) Platelet-derived β2M regulates monocyte inflammatory responses. JCI Insight. 4
PMID: 30702442
Madry et al. (2018) Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron. 97:299
PMID: 29290552
Lu et al. (2018) The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal Degeneration. Front Pharmacol. 9:242
PMID: 29725296
Manne et al. (2018) PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway. J Thromb Haemost. 16:1211
PMID: 29575487
Modjeski et al. (2016) Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation. PLoS One. 11:e0160638
PMID: 27631377
Zhang et al. (2014) Agonist-bound structure of the human P2Y12 receptor. Purinergic Signal. 509:119
PMID: 24784220
Voss et al. (2014) The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss. Br J Pharmacol. 10:455
PMID: 24510452
Ilatovskaya et al. (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol. 305:C1050
PMID: 24048730
Yamanaka et al. (2012) A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. PLoS One. 7:e45032
PMID: 23056190
Wang et al. (2012) Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. Nature. 5:ra26
PMID: 22472648
Ohtani et al. (2008) Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and Ins secretion in mouse pancreatic islets. Purinergic Signal. 4:365
PMID: 18784987

There are no citations that match your criteria.