2-Methylthioadenosine diphosphate trisodium salt

Name: 2-Methylthioadenosine diphosphate trisodium salt
Brand: Tocris Bioscience
SKU: 1624

Tocris Bioscience, part of Bio-Techne | Catalog # 1624

Citations (37)

COA / SDS

Potent agonist at P2Y1, P2Y12 and P2Y13

Key Product Details

Description:	Potent agonist at P2Y₁, P2Y₁₂ and P2Y₁₃
Alternative Names:	2-(Methylthio)adenosine 5'-diphosphate,2-Methylthio-ADP,MeSADP
Chemical Name:	2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	539.24

View Full Technical Details for 2-Methylthioadenosine diphosphate trisodium salt

Technical Data
Citations

Biological Activity for 2-Methylthioadenosine diphosphate trisodium salt

2-Methylthioadenosine diphosphate trisodium salt is a potent purinergic agonist displaying selectivity for P2Y₁, P2Y₁₂ and P2Y₁₃ receptors (pEC₅₀ = 8.29 and 9.05 for P2Y₁ and P2Y₁₂, EC₅₀ = 19 nM for P2Y₁₃). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.

Technical Data for 2-Methylthioadenosine diphosphate trisodium salt

M. Wt	539.24
Formula	C₁₁H₁₄N₅Na₃O₁₀P₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	475193-31-8
PubChem ID	52942441
InChi Key	DYNGCIHMNWOBSU-MSQVLRTGSA-K
Smiles	O[C@@H]1[C@@H](COP(OP([O-])([O-])=O)([O-])=O)O[C@@H](N3C2=NC(SC)=NC(N)=C2N=C3)[C@@H]1O.[Na+].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Methylthioadenosine diphosphate trisodium salt

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

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References for 2-Methylthioadenosine diphosphate trisodium salt

References are publications that support the biological activity of the product.

Sak and Webb A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 2002 PMID: 11747319
Zhang P2Y₁₃: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 2002 PMID: 11961076
Macfarlane 2-Methylthioadenosine[β-³²P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 1983 PMID: 6298277