2-Iodomelatonin
Tocris Bioscience, part of Bio-Techne | Catalog # 0737
High affinity melatonin agonist
Discontinued Product
0737 has been discontinued.
View all Melatonin (MT) Receptor Agonists products.
Key Product Details
Description
High affinity melatonin agonist
Product Description
2-Iodomelatonin is a potent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.Product Specifications
Molecular Weight
358.18
Formula
C13H15IN2O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide
CAS Number
93515-00-5
PubChem ID
115348
InChI Key
FJDDSMSDZHURBJ-UHFFFAOYSA-N
SMILES
COC1=CC=C2NC(I)=C(CCNC(C)=O)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.82 | 100 | |
| Ethanol | 35.82 | 100 |
Preparing Stock Solutions
for 2-Iodomelatonin
The following data is based on the product molecular weight 358.18
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.79 mL | 13.96 mL | 27.92 mL |
| 5 mM | 0.56 mL | 2.79 mL | 5.58 mL |
| 10 mM | 0.28 mL | 1.40 mL | 2.79 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dubocovich and Takahashi Use of 2-[125l]-iodomelatonin to characterize melatonin sites in chicken retina. Proc.Natl.Acad.Sci.U.S.A. 1987 PMID: 3035559
- Suiciak Quantitative pharmacological analysis of 2-[125l]-iodomelatonin binding sites in discrete areas of the chicken brain. J.Neurosci. 1991 PMID: 1652626
- Browning Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 2000 PMID: 10696085
Product Specific Notices for 2-Iodomelatonin
For research use only
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