2-Deoxy-D-glucose

Product Description

2-Deoxy-D-glucose is a non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR). 2-Deoxy-D-glucose disrupts N-glycan expression on the surface of pancreatic adenocarcinoma cells. 2-Deoxy-D-glucose enhances chimeric antigen receptor T cell activity in different xenograft mouse models of pancreatic adenocarcinoma cells.

Solubility

Preparing Stock Solutions for 2-Deoxy-D-glucose

The following data is based on the product molecular weight 164.16

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.09 mL	30.46 mL	60.92 mL
5 mM	1.22 mL	6.09 mL	12.18 mL
10 mM	0.61 mL	3.05 mL	6.09 mL
50 mM	0.12 mL	0.61 mL	1.22 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Greco Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies. Sci.Transl.Med. 2022 PMID: 35044789
• Maher Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother.Pharmacol. 2004 PMID: 14605866
• Ralser A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth. Proc.Natl.Acad.Sci.USA 2008 PMID: 19004802
• Kang and Hwang 2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 2006 PMID: 16111712