2-Chloroadenosine
Tocris Bioscience, part of Bio-Techne | Catalog # 3136
Adenosine receptor agonist
Key Product Details
Description
Adenosine receptor agonist
Alternative Names
2-CADO
Product Description
2-Chloroadenosine is a metabolically stable analog of adenosine that behaves as an adenosine receptor agonist (Ki values are 300, 80 and 1900 nM for A1, A2A and A3 receptors respectively). Anticonvulsive in vivo.Product Specifications
Molecular Weight
301.69
Formula
C10H12ClN5O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
6-Amino-2-chloropurine riboside
CAS Number
146-77-0
PubChem ID
8974
InChI Key
BIXYYZIIJIXVFW-UUOKFMHZSA-N
SMILES
O[C@@H]1[C@@H](CO)O[C@@H](N3C2=NC(Cl)=NC(N)=C2N=C3)[C@@H]1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.54 | 25 | |
| DMSO | 30.17 | 100 |
Preparing Stock Solutions
for 2-Chloroadenosine
The following data is based on the product molecular weight 301.69
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.31 mL | 16.57 mL | 33.15 mL |
| 5 mM | 0.66 mL | 3.31 mL | 6.63 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.31 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pourgholami Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures. Brain Res. 1997 PMID: 9439826
- Abdul-Ghani The protective effect of 2-chloroadenosine against the development of amygdala kindling and on amygdala-kindled seizures. Eur.J.Pharmacol. 1997 PMID: 9178649
- Mathot Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo. Br.J.Pharmacol. 1996 PMID: 8735640
Product Specific Notices for 2-Chloroadenosine
For research use only
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