2-Chloro-N6-cyclopentyladenosine
Tocris Bioscience, part of Bio-Techne | Catalog # 1705
Potent and selective A1 agonist
Key Product Details
Description
Potent and selective A1 agonist
Alternative Names
CCPA
Product Description
2-Chloro-N6-cyclopentyladenosine is a potent and selective adenosine A1 receptor agonist (Ki values are 0.8, 2300 and 42 nM for human A1, A2A and A3 receptors respectively; EC50 = 18800 nM for hA2B). Centrally active following systemic administration in vivo.Product Specifications
Molecular Weight
369.81
Formula
C15H20ClN5O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
2-Chloro-N-cyclopentyladenosine
CAS Number
37739-05-2
PubChem ID
123807
InChI Key
XSMYYYQVWPZWIZ-IDTAVKCVSA-N
SMILES
O[C@@H]1[C@@H](CO)O[C@@H](N(C=N4)C2=C4C(NC3CCCC3)=NC(Cl)=N2)[C@@H]1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.98 | 100 | |
| Ethanol | 36.98 | 100 |
Preparing Stock Solutions
for 2-Chloro-N6-cyclopentyladenosine
The following data is based on the product molecular weight 369.81
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.70 mL | 13.52 mL | 27.04 mL |
| 5 mM | 0.54 mL | 2.70 mL | 5.41 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.70 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Monopoli Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine. Arzneimittelforschung 1994 PMID: 7848348
- Klotz Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 2000 PMID: 11111832
- Lohse 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors. Naunyn Schmiedebergs Arch.Pharmacol. 1988 PMID: 3216901
- Concas Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain. J.Pharmacol.Exp.Ther. 1993 PMID: 8246158
Product Specific Notices for 2-Chloro-N6-cyclopentyladenosine
For research use only
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