2-APB

Product Description

2-APB is a functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP₃) receptor antagonist (IC₅₀ = 42 μM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μM) and inhibits it at higher concentrations (up to 50 μM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.

Solubility

Preparing Stock Solutions for 2-APB

The following data is based on the product molecular weight 225.10

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.44 mL	22.21 mL	44.42 mL
5 mM	0.89 mL	4.44 mL	8.88 mL
10 mM	0.44 mL	2.22 mL	4.44 mL
50 mM	0.09 mL	0.44 mL	0.89 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Xu Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltafe-dependent effect. Br.J.Pharmacol. 2005 PMID: 15806115
• Varnai STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPs 2009 PMID: 19187978
• Maruyama 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P₃-induced Ca²⁺ release. J.Biochem. 1997 PMID: 9348075
• Togashi Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br.J.Pharmacol. 2008 PMID: 18204483
• Bai Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB). J.Pharmacol.Exp.Ther. 2006 PMID: 16985167