2,4-Diamino-6-hydroxypyrimidine

Name: 2,4-Diamino-6-hydroxypyrimidine
Brand: Tocris Bioscience
SKU: 0476

Tocris Bioscience, part of Bio-Techne | Catalog # 0476

COA / SDS

Inhibits tetrahydrobiopterin synthesis and thus NOS activity

Discontinued Product

0476 has been discontinued. View all Additional NOS Inhibitors products.

Key Product Details

Description:	Inhibits tetrahydrobiopterin synthesis and thus NOS activity
Purity:	≥99% (HPLC)
Molecular Weight:	126.12

View Full Technical Details for 2,4-Diamino-6-hydroxypyrimidine

Technical Data
Citations

Biological Activity for 2,4-Diamino-6-hydroxypyrimidine

2,4-Diamino-6-hydroxypyrimidine is a GTP cyclohydrolase I (GCH1) inhibitor. Prevents the de novo synthesis of tetrahydrobiopterin (BH4) and thus suppresses the activity of NO synthase. Exhibits more potent inhibition of GCH1 in the presence of GFRP (GTP cyclohydrolase feedback-regulatory protein).

Technical Data for 2,4-Diamino-6-hydroxypyrimidine

M. Wt	126.12
Formula	C₄H₆N₄O
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	56-06-4
PubChem ID	2944
InChi Key	SWELIMKTDYHAOY-UHFFFAOYSA-N
Smiles	NC1=NC(N)=NC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for 2,4-Diamino-6-hydroxypyrimidine

References are publications that support the biological activity of the product.

Charles Pharmacological inhibition of guanosine triphosphate cyclohydrolase1 elevates tyrosine phosphorylation of caveolin1 and cellular senescence. Eur.J.Pharmacol. 2019 PMID: 30690003
Werner-Felmayer Pteridine biosynthesis in human endothelial cells. Impact of NO-mediated formation of cyclic GMP. J.Biol.Chem. 1993 PMID: 7678411
Xie GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine. J.Biol.Chem. 1998 PMID: 9694862
Moore and Handy Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPs 1997 PMID: 9226999

2,4-Diamino-6-hydroxypyrimidine

Tocris Bioscience, part of Bio-Techne | Catalog # 0476

Key Product Details

Biological Activity for 2,4-Diamino-6-hydroxypyrimidine

Technical Data for 2,4-Diamino-6-hydroxypyrimidine

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for 2,4-Diamino-6-hydroxypyrimidine

Product Documents for 2,4-Diamino-6-hydroxypyrimidine

COA

Certificate of Analysis

SDS

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