193 D7

Name: 193 D7
Brand: Tocris Bioscience
SKU: 8167

Tocris Bioscience, part of Bio-Techne | Catalog # 8167

COA / SDS

JMJD1C inhibitor

Key Product Details

Description:	JMJD1C inhibitor
Chemical Name:	8-Benzoyl-2,3,6,7-tetrahydro-5-oxo-5H-thiazolo[3,2-a]pyridine-6-acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	317.36

View Full Technical Details for 193 D7

Technical Data
Citations

Biological Activity for 193 D7

193 D7 is a histone demethylase JMJD1C inhibitor (IC₅₀= 0.59 μM in in vitro demethylation assay). In vivo, 193 D7 suppresses tumor by targeting intratumoral T_reg cells in mice tumor models. 193 D7 is orally bioavailable.

Technical Data for 193 D7

M. Wt	317.36
Formula	C₁₆H₁₅NO₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	861224-48-8
PubChem ID	12182298
InChi Key	DZLRINQZFUBGSQ-UHFFFAOYSA-N
Smiles	O=C(CC1C(N2C(SCC2)=C(C1)C(C3=CC=CC=C3)=O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 193 D7

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.74	100
	ethanol	6.35	20

Preparing Stock Solutions for 193 D7

The following data is based on the product molecular weight 317.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.75 mL	31.51 mL
5 mM	0.63 mL	3.15 mL	6.30 mL
10 mM	0.32 mL	1.58 mL	3.15 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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References for 193 D7

References are publications that support the biological activity of the product.

Long Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity. Nat.Immunol. 2024 PMID: 38356061