16673-34-0 NLRP3i

Tocris Bioscience, part of Bio-Techne | Catalog # 6774

NLRP3 inflammasome inhibitor
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Key Product Details

Description

NLRP3 inflammasome inhibitor

Alternative Names

JC121

View all Inflammasomes Inhibitors »

Product Description

16673-34-0 NLRP3i is a NLRP3 inflammasome inhibitor. Inhibits formation of NLRP3 inflammasome and IL-1β release in LPS and ATP-stimulated mouse macrophages and cardiomyocytes in vitro. Inhibits NLRP3 activation in mouse acute myocardial infarction and peritonitis models without affecting plasma glucose levels. Glyburide synthetic intermediate.

Product Specifications

Molecular Weight

368.84

Formula

C16H17ClN2O4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-[4-(Aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide

CAS Number

16673-34-0

PubChem ID

85542

InChI Key

KVWWTCSJLGHLRM-UHFFFAOYSA-N

SMILES

COC1=C(C(NCCC2=CC=C(S(N)(=O)=O)C=C2)=O)C=C(C=C1)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.44 50

Preparing Stock Solutions for 16673-34-0 NLRP3i

The following data is based on the product molecular weight 368.84

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.42 mL 27.11 mL 54.22 mL
2.5 mM 1.08 mL 5.42 mL 10.84 mL
5 mM 0.54 mL 2.71 mL 5.42 mL
25 mM 0.11 mL 0.54 mL 1.08 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for 16673-34-0 NLRP3i

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 16673-34-0 NLRP3i

For research use only

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