142D6
Tocris Bioscience, part of Bio-Techne | Catalog # 8018
Potent Lys-covalent pan-IAP inhibitor
Product Description
142D6 is a potent pan-IAP inhibitor (IC50 values are 21, 21 and 43 nM for cIAP1, cIAP2 and XIAP respectively). 142D6 covalently targets Lys residues in the BIR3 domain of the inhibitor of the apoptosis protein (IAP) family. In vitro, 142D6 reduces viability of cultured breast cancer MDA-MB-231 cells (EC50 values are 44 and 61 nM in cell viability and apoptosis assays, respectively). 142D6 is chemically stable in buffer and plasma and is orally bioavailable.Licensing Information
Sold under patent license from The Regents of the University of CaliforniaProduct Specifications
Molecular Weight
552.66
Formula
C26H37FN4O6S
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(R)-1-((S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-2,3-dihydro-1H-inden-4-yl sulfurofluoridate
CAS Number
2410953-19-2
InChI Key
YVERFLKIJOIKPE-HXGJMTJLSA-N
SMILES
O=C([C@H]1N(CCC1)C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)N[C@H]3C4=CC=CC(OS(F)(=O)=O)=C4CC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.27 | 100 |
Preparing Stock Solutions
for 142D6
The following data is based on the product molecular weight 552.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.81 mL | 9.05 mL | 18.09 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.62 mL |
| 10 mM | 0.18 mL | 0.90 mL | 1.81 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Udompholkul Characterization of a potent and orally bioavailable Lys-covalent inhibitor of apoptosis protein (IAP) antagonist. J.Med.Chem. 2023 PMID: 37262387
- Baggio Aryl-fluorosulfate-based lysine covalent pan-inhibitors of apoptosis protein (IAP) antagonists with cellular efficacy. J.Med.Chem. 2019 PMID: 31550155
Product Specific Notices for 142D6
For research use only
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