1-Methyl-D-tryptophan

Tocris Bioscience, part of Bio-Techne | Catalog # 5698

Indoleamine 2,3-dioxygenase (IDO) inhibitor
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Key Product Details

Description

Indoleamine 2,3-dioxygenase (IDO) inhibitor

Alternative Names

1MT

View all Indoleamine 2,3 Dioxygenase Inhibitors »

Product Description

1-Methyl-D-tryptophan is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.

Product Specifications

Molecular Weight

218.25

Formula

C12H14N2O2

Storage

Store at -20°C

Purity

≥97% (HPLC)

CAS Number

110117-83-4

PubChem ID

405012

InChI Key

ZADWXFSZEAPBJS-SNVBAGLBSA-N

SMILES

CN1C=C(C[C@H](C(O)=O)N)C2=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.09 5 with gentle warming

Preparing Stock Solutions for 1-Methyl-D-tryptophan

The following data is based on the product molecular weight 218.25

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 91.64 mL 458.19 mL 916.38 mL
0.25 mM 18.33 mL 91.64 mL 183.28 mL
0.5 mM 9.16 mL 45.82 mL 91.64 mL
2.5 mM 1.83 mL 9.16 mL 18.33 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for 1-Methyl-D-tryptophan

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 1-Methyl-D-tryptophan

For research use only

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