Summary for Simple Plex Control for Human Cyr61/CCN1
INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human Cyr61/CCN1 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.
Cyr61, also known as IGFBP-10 and CCN1, is a 50 kDa matricellular glycoprotein that regulates the growth and adhesion of vascular endothelial cells, fibroblasts, and monocytes. Cyr61 induces VEGF upregulation, angiogenesis, and tumorigenesis through interactions with integrins alpha V beta 3, alpha V beta 5, alpha M beta 2, and alpha 6 beta 1. Cyr61 is cleaved by plasmin within its VWF domain which generates an N-terminal fragment that is not associated with the matrix but retains the ability to induce endothelial cell migration.
Product Specifications for Simple Plex Control for Human Cyr61/CCN1
Species
Human
Applications
Control, Simple Plex Automated Immunoassay
Source
N/A
Preparation & Storage
Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt. • Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended. • Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.
Background: Cyr61/CCN1
Item
Value
Long Name
Cysteine-Rich, Angiogenic Inducer 61
Entrez Gene IDs
3491 (Human); 16007 (Mouse); 83476 (Rat)
Alternate Names
CCN family member 1, CCN1, CCN1IGF-binding protein 10, Cyr61, Cysteine-rich angiogenic inducer 61, GIG1, GIG1cysteine-rich heparin-binding protein 61, IBP-10, IGFBP-10, IGFBP10cysteine-rich, anigogenic inducer, 61, Insulin-like growth factor-binding protein 10, Protein GIG1, cysteine-rich, angiogenic inducer, 61, protein CYR61
