Simple Plex Control for Human COMP/Thrombospondin-5
ProteinSimple, part of Bio-Techne | Catalog # 898620
Control for use with Human COMP/Thrombospondin-5 Simple Plex Cartridge Kit
Key Product Details
Species
Human
Applications
Control, Simple Plex Automated Immunoassay
Product Summary for Simple Plex Control for Human COMP/Thrombospondin-5
INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human COMP/Thrombospondin-5 concentrations in biological fluids. Controls are supplied lyophilized. Please refer to the lot specific certificate of analysis and Simple Plex Lyophilized Quality Control product insert for additional information.
Formulation, Preparation, and Storage
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
• Store lyophilized controls at 2-8 °C. Lyophilized controls are stable for up to 12 months from date of receipt.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.
• Reconstituted controls are stable for up to 6 months from date of preparation when stored at ≤ -70 °C. Storage at -20° C is not recommended.
• Individual frozen aliquots of low and high controls are designed as single-use entities. Thaw directly before use and discard any remaining volume.
Background: COMP/Thrombospondin-5
COMP (Cartilage Oligomeric Matrix Protein), also known as Thrombospondin-5, is a multidomain calcium binding protein that associates with other extracellular matrix molecules. COMP associates into disulfide-linked homopentamers with a central hub and peripheral globular domains connected by flexible strands. An axial pore is formed by the coiled coil assembly and binds vitamin D3 which is involved in bone and cartilage metabolism. An RGD sequence in the third TSP type-3 repeat mediates chondrocyte attachment via Integrins a5b1 or aVb3. COMP is upregulated in rheumatoid arthritis and osteoarthritis, hepatocellular carcinomas, chronic pancreatitis, and pancreatic carcinomas. Several mutations in COMP are associated with skeletal dysplasias.
Long Name
Cartilage Oligomeric Matrix Protein
Alternate Names
EDM1, EPD1, MED, PSACH, Thrombospondin-5, Thrombospondin5
Gene Symbol
COMP
Additional COMP/Thrombospondin-5 Products
Product Documents for Simple Plex Control for Human COMP/Thrombospondin-5
Product Specific Notices for Simple Plex Control for Human COMP/Thrombospondin-5
For research use only
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