INTENDED USE AND DESCRIPTION: For use a pretreatment buffer to enhance protein extraction for the determination of HIV p24 concentrations in biological samples. Pretreatment K buffer is provided in a 10 mL liquid state. Please refer to the lot specific certificate of analysis and Simple Plex HIV p24 2nd Generation Cartridge product insert for additional information.
The gag gene of human immunodeficiency virus 1 (HIV-1) encodes a precursor protein known as Pr55Gag. The viral protease PR cleaves this precursor to generate p17, p24, p7, and p6 proteins which are required for virus particle assembly. p24 is a major viral core structural protein. Its measurement is commonly used as an indicator of HIV-1 infection and viral load.
Product Specifications for Pretreatment K Buffer
Species
Human
Applications
Simple Plex Automated Immunoassay
Source
N/A
Preparation & Storage
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store Pretreatment K buffer at 2-8 °C. Discard remaining buffer after opening.
Background: HIV-1 Gag p24
Item
Value
Long Name
Human Immunodeficiency Virus Type 1 GAG/Group-specific Antigen core protein of 24 kDa
Entrez Gene IDs
155030 (Viral)
Alternate Names
CA, Capsid Protein, HIV-1 Gag p24, HIV1 Gag p24, Pr55(Gag)
