Recombinant Mouse Wnt-3a Protein Best Seller

Name: Recombinant Mouse Wnt-3a Protein
Brand: R&D Systems
SKU: 1324-WN
Rating: 4 (7 reviews)

Catalog # 1324-WN | R&D Systems, Inc. a Bio-Techne Brand

(7)

Citations (195)

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Setting the standard in quality research reagents

Key Product Details

Source:	CHO
Accession #:	P27467
Applications:	Bioactivity

View Full Technical Details for Recombinant Mouse Wnt-3a Protein

Technical Data
Citations (195) / Reviews (7)

Product Specifications for Recombinant Mouse Wnt-3a Protein

Source	Chinese Hamster Ovary cell line, CHO-derived mouse Wnt-3a protein Ser19-Lys352
Purity	>75%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin level	<1.0 EU per 1 μg of the protein by the LAL method.
N-terminal sequence Analysis	Ser19
Predicted Molecular Mass	37 kDa
SDS-PAGE	37 kDa
Activity	Measured by its ability to induce alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. Fischer, L. et al. (2002) J. Biol. Chem. 277:30870. The ED₅₀ for this effect is ≤5 ng/mL. Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. Protein concentrations should be titrated based on cell type and if appropriate, passage number of the cell line. Optimal concentrations should be determined by each laboratory for each application.

Scientific Data Examples for Recombinant Mouse Wnt-3a Protein

	Recombinant Mouse Wnt-3a Protein Bioactivity Recombinant Mouse Wnt-3a (Catalog # 1324-WN) induces alkaline phosphatase production by the MC3T3-E1 mouse preosteoblast cell line. The activity is approximately 10-fold greater than the top competitor's Wnt-3A.

Formulation, Preparation and Storage

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

1324-WN

Carrier

Formulation	Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS with BSA as a carrier protein.
Reconstitution	Reconstitute at 40 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

1324-WN/CF

Carrier Free

Formulation	Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS.
Reconstitution	Reconstitute at 40 µg/mL in sterile PBS.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Wnt-3a

Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family of highly conserved cysteine-rich secreted glycoproteins important for normal developmental processes (1). Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). As intracellular beta -catenin levels rise, beta -catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes (3). Endo-IWR 1 (Catalog # 3532, # PSM1324) is a cell-permeant small molecule inhibitor of Axin turnover that suppresses Wnt signal transduction by stabilizing the beta -catenin destruction complex (4). Wnt-3a is a 44 kDa secreted hydrophobic glycoprotein containing a conserved pattern of 24 cysteine residues (5). Wnt-3a has two N-linked glycosylation sites (Asn 87, Asn 298), and Ser 209 is modified with palmitoleic acid (6). Glycosylation and acylation are essential for efficient Wnt secretion and biological activity, respectively (6, 7). Mouse Wnt-3a shares 96% amino acid (aa) identity with human Wnt-3a, and 97% with bovine and canine Wnt-3a. The rat Wnt-3a precursor shares 100% aa identity with mouse Wnt-3a aa 63-352 (8), and also shares 87% aa identity with Wnt3. During embryonic development, Wnt-3a is necessary for proper development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation (9-12). Wnt-3a also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells (13-15).

Item	Value
References	Willert, K. and Nusse, R. (2012) Cold Spring Harb. Perspect. Biol. 4:a007864. MacDonald, B.T. and X. He (2012) Cold Spring Harb. Perspect. Biol. 4:a007880. Korinek, V. et al. (1997) Science 275:1784. Chen, B. et al. (2009) Nat. Chem. Biol. 5:100. Smolich, B.D. et al. (1993) Mol. Biol. Cell 4:1267. Takada, R. et al. (2006) Dev. Cell 11:791. Komekado, H. (2007) Genes Cells 12:521. Entrez Accession # NP_001100475. Dunty Jr. W. C. et al. (2008) Development 135:85. Ikeya, M. and S. Takada (2001) Mech. Dev. 103:27. Lee, S. M. et al. (2000) Development 127:457. Takada, S. et al. (1994) Genes Dev. 8:174. Willert, K. et al. (2003) Nature 423:6938. Kalani, M.Y. et al. (2008) Proc. Natl. Acad. Sci. USA 105:16970. Ten Berge, D. et al. (2011) Nat. Cell Biol. 13:1070.
Long Name	Wingless-type MMTV Integration Site Family, Member 3a
Entrez Gene IDs	89780 (Human); 22416 (Mouse)
Alternate Names	MGC119418, MGC119419, MGC119420, Wnt-3a, Wnt3a, protein Wnt-3a, wingless-type MMTV integration site family, member 3A

Citations for Recombinant Mouse Wnt-3a Protein (195)

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Citations are publications that use Bio-Techne products. Selected citations for Recombinant Mouse Wnt-3a Protein include:

Species: Mouse
Sample Types: Whole Cell
Applications: Bioassay

Sun et al. (2023-06-16), Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration Cell reports
PMID: 37330908
Species: Transgenic Mouse
Sample Types: Organoid
Applications: Bioassay

Alber et al. (2023-06-13), Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme Nature communications
PMID: 37311756
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Robertson et al. (2023-05-26), Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/?-catenin to induce exit from quiescence Cell reports
PMID: 37243590
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Li et al. (2023-04-07), Characterization of Inflammatory Signals in BV-2 Microglia in Response to Wnt3a Biomedicines
PMID: 37189739
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

LA Dada et al. (2023-02-22), Hypercapnia alters stromal-derived Wnt production limiting beta-catenin signaling and proliferation in alveolar type 2 cells JCI Insight, 2023-00(0).
PMID: 36626234
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Nomura et al. (2023-02-16), Simple Detection and Culture of Circulating Tumor Cells from Colorectal Cancer Patients Using Poly(2-Methoxyethyl Acrylate)-Coated Plates International Journal of Molecular Sciences, 2023-024(4).
PMID: 36835361
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

YF Wong et al. (2023-01-23), Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation Nature Cell Biology, 2023-00(0).
PMID: 36690849
Species: Human
Sample Types: Organoids
Applications: Bioassay

Y Niu et al. (2022-12-05), Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select Nature Genetics, 2022-154(12):1983-1993.
PMID: 36471068
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Pentinmikk et al. (2022-10-14), Cellular shape reinforces niche to stem cell signaling in the small intestine Science Advances, 2022-18(41):eabm1847.
PMID: 36240269
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

G Pizzolato et al. (2022-10-10), The oncogenic transcription factor FOXQ1 is a differential regulator of Wnt target genes Journal of Cell Science, 2022-10(0).
PMID: 36124643
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay

H Marei et al. (2022-09-21), Antibody targeting of E3 ubiquitin ligases for receptor degradation Nature, 2022-0610(7930):182-189.
PMID: 36131013
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Z Wang et al. (2022-09-19), Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm Nature Communications, 2022-013(1):5447.
PMID: 36123357
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Mita et al. (2022-07-29), R-spondin3 is a myokine that differentiates myoblasts to type I fibres Scientific Reports, 2022-012(1):13020.
PMID: 35906363
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

G Liu et al. (2022-07-28), Functionalized 3D-Printed ST2/Gelatin Methacryloyl/Polcaprolactone Scaffolds for Enhancing Bone Regeneration with Vascularization International Journal of Molecular Sciences, 2022-023(15).
PMID: 35955478
Species: Mouse
Sample Types: Organoids
Applications: Bioassay

G Jacquemin et al. (2022-05-11), Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme Elife, 2022-011(0).
PMID: 35543624
Species: Mouse
Sample Types: Whole Cell
Applications: Cell Culture

Y Zhang et al. (2022-05-04), Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/beta-catenin signaling in obstructed kidneys in vivo The Journal of Biological Chemistry, 2022-00(0):102010.
PMID: 35525270
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

S Mancarella et al. (2022-04-10), The Tumor Microenvironment Drives Intrahepatic Cholangiocarcinoma Progression International Journal of Molecular Sciences, 2022-023(8).
PMID: 35457006
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

K Komatsu et al. (2022-02-25), Platelet-derived growth factor-BB regenerates functional periodontal ligament in the tooth replantation Scientific Reports, 2022-012(1):3223.
PMID: 35217688
Species: Mouse
Sample Types: Organoids
Applications: Bioassay

S Watanabe et al. (2022-02-02), Transplantation of intestinal organoids into a mouse model of colitis Nature Protocols, 2022-00(0).
PMID: 35110738
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CM Termini et al. (2021-11-30), Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution Nature Communications, 2021-112(1):6990.
PMID: 34848712
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RJ Geusz et al. (2021-11-17), Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors Nature Communications, 2021-112(1):6636.
PMID: 34789735
Species: Mouse
Sample Types: Organoids
Applications: Bioassay

S Heino et al. (2021-11-17), Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas Science Advances, 2021-17(47):eabj0512.
PMID: 34788095
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Shen et al. (2021-09-06), The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling Nature Communications, 2021-012(1):5263.
PMID: 34489457
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Aaron et al. (2021-06-22), Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells Elife, 2021-010(0).
PMID: 34155972
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Weinstock et al. (2021-03-15), Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis Elife, 2021-010(0).
PMID: 33720008
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

M Jurásek et al. (2021-01-15), Phosphorylation-induced changes in the PDZ domain of Dishevelled 3 Scientific Reports, 2021-011(1):1484.
PMID: 33452274
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KA Radaszkiew et al. (2020-09-28), 12-O-Tetradecanoylphorbol-13-acetate increases cardiomyogenesis through PKC/ERK signaling Sci Rep, 2020-010(1):15922.
PMID: 32985604
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

DP Bagchi et al. (2020-09-09), Wnt/&beta-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells Mol Metab, 2020-042(0):101078.
PMID: 32919095
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Y Kiyokawa et al. (2020-09-02), Drug-Induced Naï¿½ve iPS Cells Exhibit Better Performance than Primed iPS Cells with Respect to the Ability to Differentiate into Pancreatic &beta-Cell Lineage Journal of Clinical Medicine, 2020-09(9).
PMID: 32887316
Species: Mouse
Sample Types: Organoids, Whole Cells
Applications: Bioassay

Y Miao et al. (2020-08-19), Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy Inï¿½Vivo Cell Stem Cell, 2020-00(0).
PMID: 32818433
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

B Ma et al. (2020-08-11), Differential Histone Distribution Patterns in Induced Asymmetrically Dividing Mouse Embryonic Stem Cells Cell Rep, 2020-032(6):108003.
PMID: 32783931
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

L Zhang et al. (2020-08-11), Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State Cell Stem Cell, 2020-00(0).
PMID: 32783886
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

SY Jeong et al. (2020-07-28), Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling Exp. Mol. Med., 2020-00(0).
PMID: 32724069
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

NK Vinckier et al. (2020-04-29), LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development Nat Commun, 2020-011(1):2082.
PMID: 32350257
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

DP Bagchi et al. (2020-04-20), Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction Mol Metab, 2020-00(0):100992.
PMID: 32325263
Species: Mouse
Sample Types: Colon
Applications: Cell Culture

H Lee et al. (2020-04-06), Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways Theranostics, 2020-010(11):5048-5063.
PMID: 32308767
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

D Gay et al. (2020-03-20), Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing Sci Adv, 2020-06(12):eaay3704.
PMID: 32219160
Species: Rat

Applications: Cell Culture

M Mecha et al. (2020-03-19), Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis J Neuroinflammation, 2020-017(1):88.
PMID: 32192522
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

I Betella et al. (2020-03-16), Wnt signaling modulator DKK1 as an immunotherapeutic target in ovarian cancer Gynecol. Oncol., 2020-00(0).
PMID: 32192732
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

A Kawashima et al. (2020-03-04), Engraftment potential of maternal adipose-derived stem cells for fetal transplantation Heliyon, 2020-06(3):e03409.
PMID: 32154403
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Y Wada et al. (2020-02-26), Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice PLoS Genet., 2020-016(2):e1008628.
PMID: 32101538
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

CJ Aros et al. (2020-02-18), High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis Cell Rep, 2020-030(7):2055-2064.e5.
PMID: 32075752
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

W Liang et al. (2019-12-30), Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells Stem Cells, 2019-10(0).
PMID: 31648393
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

JP Sah et al. (2019-12-02), Ectonucleotide pyrophosphatase 2 (ENPP2) plays a crucial role in myogenic differentiation through the regulation by WNT/beta-Catenin signaling Int. J. Biochem. Cell Biol., 2019-1118(0):105661.
PMID: 31805399
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

D Zhou et al. (2019-11-14), Sonic hedgehog connects podocyte injury to mesangial activation and glomerulosclerosis JCI Insight, 2019-14(22).
PMID: 31647783
Species: Mouse
Sample Types: Cell Lysates
Applications: Bioassay

N Chen et al. (2019-10-15), The transcription factor NKX1-2 promotes adipogenesis and may contribute to a balance between adipocyte and osteoblast differentiation J. Biol. Chem., 2019-10(0).
PMID: 31615896
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

FM Cernilogar et al. (2019-09-26), Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2 Nucleic Acids Res., 2019-00(0).
PMID: 31350899
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C Lee et al. (2019-09-02), NOD2 Supports Crypt Survival and Epithelial Regeneration after Radiation-Induced Injury Int J Mol Sci, 2019-020(17).
PMID: 31480799
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

S Saraswati et al. (2019-07-09), Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing Nat Commun, 2019-010(1):3027.
PMID: 31289275
Species: Transgenic Mouse
Sample Types: Organoid
Applications: Bioassay

C Yoon et al. (2019-06-19), KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis Mol. Cancer Res., 2019-00(0).
PMID: 31217166
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KL VanDussen et al. (2019-03-27), L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams Stem Cell Res, 2019-037(0):101430.
PMID: 30933720
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

P Shooshtari et al. (2019-03-20), Gfi1b regulates the level of Wnt/?-catenin signaling in hematopoietic stem cells and megakaryocytes Nat Commun, 2019-010(1):1270.
PMID: 30894540
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Chapellier et al. (2019-02-28), Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells Haematologica, 2019-00(0).
PMID: 30819903
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Ooi et al. (2019-02-26), Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects Cell Rep, 2019-026(9):2494-2508.e7.
PMID: 30811996
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Qian et al. (2018-12-04), Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice Aging (Albany NY), 2018-10(0).
PMID: 30513510
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

YB Hu et al. (2018-11-02), Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance Oncogene, 2018-10(0).
PMID: 30390075
Species: Mouse
Sample Types: Organoids
Applications: Bioassay

S Olabi et al. (2018-10-22), Integrin-Rac signalling for mammary epithelial stem cell self-renewal Breast Cancer Res., 2018-120(1):128.
PMID: 30348189
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Yoney et al. (2018-10-12), WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids Elife, 2018-17(0).
PMID: 30311909
Species: Mouse
Sample Types: Organoids
Applications: Bioassay

Y Xie et al. (2018-08-25), Long-term organoid culture reveals enrichment of organoid-forming epithelial cells in the fimbrial portion of mouse fallopian tube Stem Cell Res, 2018-032(0):51-60.
PMID: 30176443
Species: Mouse

P Andersen et al. (2018-08-07), Precardiac organoids form two heart fields via Bmp/Wnt signaling Nat Commun, 2018-09(1):3140.
PMID: 30087351
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

E López-Arri et al. (2018-07-31), Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells Nat Commun, 2018-09(1):2992.
PMID: 30065304
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Spangler et al. (2018-07-29), A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo Stem Cell Res, 2018-031(0):201-215.
PMID: 30118958
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HE Ahrens et al. (2018-07-04), Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle Skelet Muscle, 2018-08(1):20.
PMID: 29973273
Species: Mouse
Sample Types: Whole Tissue

Y Muta et al. (2018-06-05), Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine Nat Commun, 2018-09(1):2174.
PMID: 29872037
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Matsuoka et al. (2018-05-11), WAIF1 is a cell-surface CTHRC1 binding protein coupling bone resorption and formation J. Bone Miner. Res., 2018-00(0).
PMID: 29624737
Species: Mouse
Sample Types: Tissue Explant
Applications: Bioassay

W Liu et al. (2018-05-04), Wnt signaling activates TIGAR and protects against cisplatin-induced spiral ganglion neuron damage in the mouse cochlea Antioxid. Redox Signal., 2018-00(0).
PMID: 29587485
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

JA Ríos et al. (2018-04-11), Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3Î²-AMPK axis Cell Commun. Signal, 2018-016(1):15.
PMID: 29642895
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

J Li et al. (2018-04-06), Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC Nucleic Acids Res., 2018-00(0).
PMID: 29394393
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Held et al. (2018-03-17), Targeting ?-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage Osteoarthr. Cartil., 2018-00(0).
PMID: 29559252
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

F Zhao et al. (2018-01-16), Paracrine Wnt5a-?-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization Immunity, 2018-048(1):147-160.e7.
PMID: 29343435
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MH Kwack et al. (2018-01-10), Establishment and characterization of five immortalized human scalp dermal papilla cell lines Biochem. Biophys. Res. Commun., 2018-00(0).
PMID: 29331373
Species: Mouse
Sample Types: Organoids
Applications: Organoid Culture

Y Kasagi et al. (2018-01-03), The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelialï¿½Changes Cell Mol Gastroenterol Hepatol, 2018-05(3):333-352.
PMID: 29552622
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Chen et al. (2017-12-19), Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse Cell Discov, 2017-13(0):17046.
PMID: 29263795
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

YY Sin et al. (2017-12-01), Transplantation of Gene-Edited Hepatocyte-like Cells Modestly Improves Survival of Arginase-1-Deficient Mice Mol Ther Nucleic Acids, 2017-110(0):122-130.
PMID: 29499927
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MW Susman et al. (2017-09-08), Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates Elife, 2017-06(0).
PMID: 28885975
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

P Paclíková et al. (2017-08-28), N-terminal part of Dishevelled DEP domain is required for Wnt/?-catenin signaling in mammalian cells Mol. Cell. Biol., 2017-00(0).
PMID: 28674183
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KF Cogger et al. (2017-08-24), Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors Nat Commun, 2017-08(1):331.
PMID: 28835709
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

B Li et al. (2017-07-06), Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes Stem Cell Reports, 2017-00(0).
PMID: 28689996
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

M Lowndes et al. (2017-06-29), Constructing cellular niche properties by localized presentation of Wnt proteins on synthetic surfaces Nat Protoc, 2017-012(7):1498-1512.
PMID: 28686585
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

YY Sin et al. (2017-05-31), Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency Sci Rep, 2017-07(1):2585.
PMID: 28566761
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

T Tammela et al. (2017-05-10), A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma Nature, 2017-0545(7654):355-359.
PMID: 28489818
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

ZZ Wei et al. (2017-04-21), Neuroprotective and regenerative roles of intranasal Wnt-3a Administration after focal ischemic stroke in mice J. Cereb. Blood Flow Metab., 2017-00(0):271678X177026.
PMID: 28430000
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Y Zhang (2017-04-17), Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/?-catenin signaling Biochem. Biophys. Res. Commun., 2017-00(0).
PMID: 28427938
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

KB McCauley et al. (2017-03-30), Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling Cell Stem Cell, 2017-00(0).
PMID: 28366587
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

K Wilk et al. (2017-03-30), Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration Stem Cell Reports, 2017-00(0).
PMID: 28366454
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

J Zhang et al. (2017-03-25), Activation of Wnt3?/?-catenin signal pathway attenuates apoptosis of the cerebral microvascular endothelial cells induced by oxygen-glucose deprivation Biochem. Biophys. Res. Commun, 2017-00(0).
PMID: 28347817
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

L Li et al. (2017-03-24), Acceleration of bone regeneration by activating Wnt/?-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis Sci Rep, 2017-07(0):45204.
PMID: 28338064
Species: Human
Sample Types: Cell Lysates
Applications: Bioassay

MB Furtado et al. (2017-03-23), Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling JCI Insight, 2017-02(6):e88271.
PMID: 28352650
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MJ Rodríguez- et al. (2017-03-08), Interplay between metabolic identities in the intestinal crypt supports stem cell function Nature, 2017-0543(7645):424-427.
PMID: 28273069
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

F Lacour et al. (2017-03-07), R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways Cell Rep, 2017-018(10):2320-2330.
PMID: 28273449
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

N Cerdá-Este et al. (2017-02-13), Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2 Nat Commun, 2017-08(0):14127.
PMID: 28193997
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lebensohn A et al. (2016-12-20), Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling. Elife, 2016-15(0).
PMID: 27996937
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hoeke A Baarsma (2016-12-15), Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD J. Exp. Med, 2016-10(0).
PMID: 27979969
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016-12-05), Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms Nat. Med, 2016-10(0).
PMID: 27918563
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Joan Massagué (2016-11-23), The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells Cell Stem Cell, 2016-10(0).
PMID: 27889317
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Muruganandan S et al. (2016-11-11), Chemokine-Like Receptor 1 Is a Novel Wnt Target Gene that Regulates Mesenchymal Stem Cell Differentiation. Stem Cells, 2016-135(3):711-724.
PMID: 27733019
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016-09-23), Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose PLoS ONE, 2016-011(9):e0163580.
PMID: 27662374
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

(2016-08-26), Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism PLoS ONE, 2016-011(8):e0162049.
PMID: 27564706
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016-08-24), Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a-induced Autophagy in Pancreatic Intraepithelial Neoplasms J Biol Chem, 2016-00(0).
PMID: 27557659
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2016-07-20), Diverse Functions of Retinoic Acid in Brain Vascular Development J Neurosci, 2016-036(29):7786-801.
PMID: 27445154
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Ting Cai (2016-06-16), WNT/?-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression Exp Cell Res, 2016-00(0).
PMID: 27321958
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

PJ Attayek et al. (2016-04-21), In Vitro Polarization of Colonoids to Create an Intestinal Stem Cell Compartment PLoS ONE, 2016-011(4):e0153795.
PMID: 27100890
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CM Karner et al. (2016-04-20), Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation J. Biol. Chem., 2016-0291(25):13028-39.
PMID: 27129247
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Marie-Isabelle Garcia (2016-03-17), Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage Development, 2016-0143(9):1452-63.
PMID: 26989172
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Morrison G et al. (2015-12-16), Convergence of cMyc and beta-catenin on Tcf7l1 enables endoderm specification. EMBO J, 2015-135(3):356-68.
PMID: 26675138
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lu W et al. (2015-07-20), Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nat Cell Biol, 2015-017(8):971-83.
PMID: 26192438
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Beier E et al. (2015-05-14), Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/beta-CATENIN SIGNALING PATHWAY. J Biol Chem, 2015-0290(29):18216-26.
PMID: 25975268
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Amador-Arjona et al. (2015-03-30), SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis. Proc Natl Acad Sci U S A, 2015-0112(15):E1936-45.
PMID: 25825708
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chang B et al. (2015-03-16), Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun, 2015-06(0):6380.
PMID: 25871009
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Bioassay

Suzuki A et al. (2015-03-09), WNT/beta-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets. Mol Cell Biol, 2015-035(10):1763-76.
PMID: 25755281
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Suryawanshi A et al. (2015-02-20), Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation. J Immunol, 2015-0194(7):3295-304.
PMID: 25710911
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhang L et al. (2015-02-18), Inhibited Wnt signaling causes age-dependent abnormalities in the bone matrix mineralization in the Apert syndrome FGFR2(S252W/+) mice. PLoS ONE, 2015-010(2):e112716.
PMID: 25693202
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tao S et al. (2015-01-21), Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage. EMBO J, 2015-034(5):624-40.
PMID: 25609789
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Alshbool F et al. (2014-12-05), Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis. PLoS ONE, 2014-19(12):e114357.
PMID: 25479235
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ramsey S et al. (2014-12-04), Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway. PLoS Genet, 2014-110(12):e1004828.
PMID: 25474352
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ouji Y et al. (2014-12-01), Partial maintenance and long-term expansion of murine skin epithelial stem cells by Wnt-3a in vitro. J Invest Dermatol, 2014-1135(6):1598-608.
PMID: 25437427
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Noguchi et al. (2014-09-05), Induction of tissue-specific stem cells by reprogramming factors, and tissue-specific selection. Cell Death Differ, 2014-022(1):145-55.
PMID: 25190146
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gouti et al. (2014-08-26), In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity. PLoS Biol, 2014-012(8):e1001937.
PMID: 25157815
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Komiya Y et al. (2014-08-25), Custos controls beta-catenin to regulate head development during vertebrate embryogenesis. Proc Natl Acad Sci U S A, 2014-0111(36):13099-104.
PMID: 25157132
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cambier L et al. (2014-08-01), Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development, 2014-0141(15):2959-71.
PMID: 25053429
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhu Q et al. (2014-06-14), The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways. Elife, 2014-03(0).
PMID: 24929964
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gao B et al. (2014-06-11), Dose-dependent effect of estrogen suppresses the osteo-adipogenic transdifferentiation of osteoblasts via canonical Wnt signaling pathway. PLoS ONE, 2014-09(6):e99137.
PMID: 24918446
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zhu et al. (2014-06-09), Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. J Clin Invest, 2014-0124(7):3263-73.
PMID: 24911145
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Liu Y et al. (2014-06-01), Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells. Stem Cells, 2014-032(6):1515-26.
PMID: 24585688
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Poh Y et al. (2014-05-30), Generation of organized germ layers from a single mouse embryonic stem cell. Nat Commun, 2014-05(0):4000.
PMID: 24873804
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Weinert S et al. (2014-05-12), Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions. EMBO Rep, 2014-015(7):784-91.
PMID: 24820037
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lewandowski J et al. (2014-04-17), Manipulating gene expression and signaling activity in cultured mouse limb bud cells. Dev Dyn, 2014-0243(7):928-36.
PMID: 24633820
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bentzinger C et al. (2014-04-07), Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. J Cell Biol, 2014-0205(1):97-111.
PMID: 24711502
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Koraishy F et al. (2014-04-01), Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling. J Biol Chem, 2014-0289(20):14341-50.
PMID: 24692544
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Okamoto M et al. (2014-03-27), Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis. Sci Rep, 2014-04(0):4493.
PMID: 24670389
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yu C et al. (2014-03-07), Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. Eur J Immunol, 2014-044(5):1480-90.
PMID: 24643512
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tsakiridis et al. (2014-03-01), Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors. Development, 2014-0141(6):1209-21.
PMID: 24595287
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Go G et al. (2014-02-04), The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. Cell Metab, 2014-019(2):209-20.
PMID: 24506864
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chen J et al. (2014-01-30), WNT7B promotes bone formation in part through mTORC1. PLoS Genet, 2014-010(1):e1004145.
PMID: 24497849
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Raggioli A et al. (2014-01-21), Beta-catenin is vital for the integrity of mouse embryonic stem cells. PLoS ONE, 2014-09(1):e86691.
PMID: 24466203
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Stapp A et al. (2014-01-17), Canonical WNT signaling inhibits follicle stimulating hormone mediated steroidogenesis in primary cultures of rat granulosa cells. PLoS ONE, 2014-09(1):e86432.
PMID: 24466091
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dhamdhere et al. (2014-01-06), Drugging a stem cell compartment using Wnt3a protein as a therapeutic. PLoS ONE, 2014-09(1):e83650.
PMID: 24400074
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Lei N et al. (2014-01-06), Intestinal subepithelial myofibroblasts support the growth of intestinal epithelial stem cells. PLoS ONE, 2014-09(1):e84651.
PMID: 24400106
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Kohler et al. (2013-12-30), Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells. PLoS ONE, 2013-18(12):e85549.
PMID: 24386480
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ishikawa M et al. (2013-12-12), Pannexin 3 inhibits proliferation of osteoprogenitor cells by regulating Wnt and p21 signaling. J Biol Chem, 2013-1289(5):2839-51.
PMID: 24338011
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Boschert V et al. (2013-11-29), Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition. PLoS ONE, 2013-18(11):e81710.
PMID: 24312339
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Stalvey M et al. (2013-11-13), Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease. PLoS ONE, 2013-18(11):e80098.
PMID: 24236172
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Nishino et al. (2013-11-05), A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife, 2013-12(0):e00924.
PMID: 24192035
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Salazar V et al. (2013-10-07), Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with beta-catenin. J Cell Sci, 2013-1126(0):5598-609.
PMID: 24101723
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Xavier C et al. (2013-09-28), Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling. Cell Signal, 2013-026(1):94-101.
PMID: 24080158
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Yang J et al. (2013-09-27), BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells. Exp Cell Res, 2013-0320(1):54-61.
PMID: 24080013
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Zhou et al. (2013-07-31), Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection. Nature, 2013-0501(7465):107-11.
PMID: 23903657
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Busch A et al. (2013-04-28), Evidence for tankyrases as antineoplastic targets in lung cancer. BMC Cancer, 2013-013(0):211.
PMID: 23621985
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Huynh D et al. (2013-02-22), CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response. PLoS ONE, 2013-08(2):e56951.
PMID: 23451116
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

(2013-01-23), Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A, 2013-0110(6):2324-9.
PMID: 23345421
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mae et al. (2013-01-01), Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun, 2013-04(0):1367.
PMID: 23340407
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Halleskog C et al. (2012-12-22), Pertussis toxin-sensitive heterotrimeric G(alphai/o) proteins mediate WNT/beta-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A. Cell Signal, 2012-125(4):822-8.
PMID: 23266471
Species: Mouse
Sample Types: Whole Cells

Sneddon et al. (2012-10-07), Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature, 2012-1491(7426):765-8.
PMID: 23041930
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Walker et al. (2012-09-04), Prolactin stimulates precursor cells in the adult mouse hippocampus. PLoS ONE, 2012-07(9):e44371.
PMID: 22973440
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tran et al. (2012-08-03), Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem, 2012-0287(39):32651-64.
PMID: 22865881
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tran H et al. (2012-07-03), Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the beta-catenin destruction complex. J Biol Chem, 2012-0287(34):28552-63.
PMID: 22761442
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

(2012-05-04), Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis. Cell Death Differ., 2012-019(11):1761-8.
PMID: 22555459
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Goel S et al. (2012-03-20), Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts. J. Biol. Chem., 2012-0287(20):16454-66.
PMID: 22433869
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wang P et al. (2012-02-29), A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev, 2012-021(12):2273-87.
PMID: 22236333
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Palsgaard J et al. (2012-02-15), Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). J. Biol. Chem., 2012-0287(15):12016-26.
PMID: 22337886
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Nakamura et al. (2012-01-01), Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA. Nat Commun, 2012-03(0):1322.
PMID: 23271656
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kelly OG et al. (2011-07-31), Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Nat. Biotechnol., 2011-029(8):750-6.
PMID: 21804561
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Tsai SY et al. (2011-06-01), Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells. Stem Cells, 2011-029(6):964-71.
PMID: 21563278
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Krause C et al. (2010-10-15), Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways. J. Biol. Chem., 2010-1285(53):41614-26.
PMID: 20952383
Species: Human
Sample Types: Recombinant Protein
Applications: Binding Assay

Gong Y et al. (2010-09-13), Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies. PLoS ONE, 2010-05(9):e12682.
PMID: 20856934
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Del Debbio CB et al. (2010-08-26), Notch and Wnt signaling mediated rod photoreceptor regeneration by Muller cells in adult mammalian retina. PLoS ONE, 2010-05(8):e12425.
PMID: 20865053
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture

Roelandt P et al. (2010-08-11), Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE, 2010-05(8):e12101.
PMID: 20711405
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Trowbridge JJ et al. (2010-08-01), Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity. Stem Cells, 2010-028(8):1379-89.
PMID: 20521329
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kawaguchi J et al. (2010-03-01), Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos. Development, 2010-0137(5):693-704.
PMID: 20147374
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gustafson B et al. (2010-02-23), Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance. J. Biol. Chem., 2010-0285(18):14031-41.
PMID: 20179324
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Steele BM et al. (2009-11-09), Canonical Wnt signaling negatively regulates platelet function. Proc. Natl. Acad. Sci. U.S.A., 2009-1106(47):19836-41.
PMID: 19901330
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Gogolla N et al. (2009-05-28), Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus. Neuron, 2009-062(4):510-25.
PMID: 19477153
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hansson M et al. (2009-04-07), A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev. Biol., 2009-0330(2):286-304.
PMID: 19358838
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Borowiak M et al. (2009-04-03), Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell, 2009-04(4):348-58.
PMID: 19341624
Species: Human
Sample Types: N/A, Whole Cells
Applications: Bioassay, Receptor Binding Assay

Liu CC et al. (2009-03-31), Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains. J. Biol. Chem., 2009-0284(22):15299-307.
PMID: 19339249
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Kim SE et al. (2009-02-24), H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation. J. Cell. Sci., 2009-0122(0):842-8.
PMID: 19240121
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Shafer SL et al. (2009-01-21), Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element. J. Mol. Cell. Cardiol., 2009-046(5):621-35.
PMID: 19344627
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Wan M et al. (2008-11-01), Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes Dev., 2008-122(21):2968-79.
PMID: 18981475
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kennell JA et al. (2008-09-29), The microRNA miR-8 is a conserved negative regulator of Wnt signaling. Proc. Natl. Acad. Sci. U.S.A., 2008-0105(40):15417-22.
PMID: 18824696
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Verkaar F et al. (2008-09-25), Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Cell. Signal., 2008-021(1):22-33.
PMID: 18929644
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Nakanishi M et al. (2008-09-22), Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium. FASEB J., 2008-023(1):114-22.
PMID: 18809738
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Endo Y et al. (2008-01-22), Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Mol. Cell. Biol., 2008-028(7):2368-79.
PMID: 18212053
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Elkabetz Y et al. (2008-01-15), Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev., 2008-022(2):152-65.
PMID: 18198334
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo

Anderson BC et al. (2008-01-01), Myogenic growth factors can decrease extraocular muscle force generation: a potential biological approach to the treatment of strabismus. Invest. Ophthalmol. Vis. Sci., 2008-049(1):221-9.
PMID: 18172096
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cho YM et al. (2007-12-04), Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells. Biochem. Biophys. Res. Commun., 2007-1366(1):129-34.
PMID: 18060872
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Zhang P et al. (2007-11-27), Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood, 2007-1111(4):1933-41.
PMID: 18042803
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Giuliani N et al. (2007-08-15), Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment. Cancer Res., 2007-067(16):7665-74.
PMID: 17702698
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Kwon C et al. (2007-06-18), Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc. Natl. Acad. Sci. U.S.A., 2007-0104(26):10894-9.
PMID: 17576928
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Rydziel S et al. (2007-05-10), Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. J. Biol. Chem., 2007-0282(27):19762-72.
PMID: 17500060
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wawrzak D et al. (2007-04-19), Wnt3a binds to several sFRPs in the nanomolar range. Biochem. Biophys. Res. Commun., 2007-0357(4):1119-23.
PMID: 17462603
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Miyabayashi T et al. (2007-03-19), Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc. Natl. Acad. Sci. U.S.A., 2007-0104(13):5668-73.
PMID: 17372190
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay

Canning CA et al. (2007-02-16), Sustained interactive Wnt and FGF signaling is required to maintain isthmic identity. Dev. Biol., 2007-0305(1):276-86.
PMID: 17383629
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay

Nordstrom U et al. (2006-07-01), An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity. PLoS Biol., 2006-04(8):e252.
PMID: 16895440
Species: Chicken
Sample Types: In Vivo
Applications: In Vivo

Yue Z et al. (2006-01-17), Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia. Proc. Natl. Acad. Sci. U.S.A., 2006-0103(0):951-5.
PMID: 16418297
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Corti S et al. (2005-09-08), Multipotentiality, homing properties, and pyramidal neurogenesis of CNS-derived LeX(ssea-1)+/CXCR4+ stem cells. FASEB J., 2005-019(13):1860-2.
PMID: 16150803

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Recombinant Mouse Wnt-3a Protein

Name: Anonymous

Application: In vitro bioactivity in cell culture

Verified Customer | Posted 08/31/2023

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Thank you for reviewing our product. We are sorry to hear that this product did not perform as expected. We have been in touch with the customer to resolve this issue according to our Product Guarantee and to the customer’s satisfaction.
Recombinant Mouse Wnt-3a Protein

Name: Xun Lin

Application: Stem/Immune cell maintenance or differentiation

Verified Customer | Posted 06/16/2020
Recombinant Mouse Wnt-3a Protein

Name: Zheng Wei

Application: In vivo study

Verified Customer | Posted 10/25/2017
Recombinant Mouse Wnt-3a Protein

Name: Anonymous

Application: In vivo study

Verified Customer | Posted 09/08/2017
Recombinant Mouse Wnt-3a Protein

Name: James Waire

Application: Stem/Immune cell maintenance or differentiation

Reason for Rating: Consistent and expect bioactive in our cell culture assays. Also expected protein concentration

Verified Customer | Posted 05/16/2017

Use rec Wnt in the growth and differentiation of cultures.
Recombinant Mouse Wnt-3a Protein

Name: Anonymous

Application: Stem/Immune cell maintenance or differentiation

Verified Customer | Posted 07/21/2016
Recombinant Mouse Wnt-3a Protein

Name: Anonymous

Application: Stem/Immune cell maintenance or differentiation

Reason for Rating: reproducible results

Verified Customer | Posted 05/17/2016

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