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Recombinant Human Cathepsin V Protein, CF

Catalog # 1080-CY | R&D Systems, Inc. a Bio-Techne Brand
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1080-CY-010

Key Product Details

Source

NS0

Accession #

Structure / Form

Pro form

Conjugate

Unconjugated

Applications

Enzyme Activity

Product Specifications

Source

Mouse myeloma cell line, NS0-derived human Cathepsin V protein
Val18-Val334, with a C-terminal 10-His tag

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Endotoxin Level

<1.0 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Val18

Predicted Molecular Mass

37 kDa

SDS-PAGE

40 kDa, reducing conditions

Activity

Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC (Catalog # ES008).
The specific activity is >400 pmol/min/µg, as measured under the described conditions.

Formulation, Preparation and Storage

1080-CY
Formulation Supplied as a 0.2 μm filtered solution in Sodium Acetate and NaCl.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -20 to -70 °C as supplied.
  • 3 months, -20 to -70 °C under sterile conditions after opening.

Background: Cathepsin V

Cathepsin V (also known as Cathepsin L2 and U) is a cysteine protease of the papain family (1). It is expressed as a proenzyme in lysosomes, which can be autocatalytically converted to the mature form at pH 4.0 (2). Cathepsin V shows high amino acid identity with Cathepsin L (77% for the proenzymes and 80% for the mature enzymes) (3). However, Cathepsin V is specifically expressed in the thymus, testis, and corneal epithelium whereas Cathepsin L is expressed throughout the body.

References

  1. Turk, V. et al. (2001) EMBO J. 20:4629.
  2. Bromme, D. et al. (1999) Biochemistry 38:2377.
  3. Somoza, J.R. et al. (2000) Biochemistry 39:12543.

Alternate Names

Cathepsin L2, Cathepsin U, CTSL2

Entrez Gene IDs

1515 (Human)

Gene Symbol

CTSV

UniProt

Product Documents for Recombinant Human Cathepsin V Protein, CF

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Recombinant Human Cathepsin V Protein, CF

For research use only

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