Trolox
Tocris Bioscience, part of Bio-Techne | Catalog # 6002
Antifade reagent; antioxidant vitamin E derivative; cell permeable and water soluble
Key Product Details
Description
Antifade reagent; antioxidant vitamin E derivative; cell permeable and water soluble
Product Description
Trolox is an antioxidant vitamin E derivative; suppresses osteoclast formation and inhibits IL-1-induced osteoclast bone loss. Also inhibits ferroptosis. Commonly used antifade reagent in live cell imaging; suppresses blinking and photobleaching. Cell-permeable and water soluble.Spectra Viewer
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Product Specifications
Molecular Weight
250.29
Formula
C14H18O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
CAS Number
53188-07-1
PubChem ID
40634
InChI Key
GLEVLJDDWXEYCO-UHFFFAOYSA-N
SMILES
CC1=C(C(C)=C2CCC(OC2=C1C)(C(O)=O)C)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.03 | 100 | |
| Ethanol | 25.03 | 100 |
Preparing Stock Solutions
for Trolox
The following data is based on the product molecular weight 250.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.00 mL | 19.98 mL | 39.95 mL |
| 5 mM | 0.80 mL | 4.00 mL | 7.99 mL |
| 10 mM | 0.40 mL | 2.00 mL | 4.00 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Cordes On the mechanism of Trolox as antiblinking and antibleaching reagent. J.Am.Chem.Soc. 2009 PMID: 19301868
- Lee Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling. J.Biol.Chem. 2009 PMID: 19299513
- Xie Ferroptosis: process and function. Cell Death Differ. 2016 PMID: 26794443
- Giulivi Inhibition of protein radical reactions of ferrylmyoglobin by the water-soluble analog of vitamin E, Trolox C. Arch.Biochem.Biophys. 1993 PMID: 8489259
Product Specific Notices for Trolox
For research use only
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