Se-NADA
Tocris Bioscience, part of Bio-Techne | Catalog # 7449
Orange fluorescent benzoselenadiazole D-amino acid (FDAA) for imaging bacteria; also photosensitizer
Key Product Details
Description
Orange fluorescent benzoselenadiazole D-amino acid (FDAA) for imaging bacteria; also photosensitizer
Product Description
Se-NADA is an orange fluorescent benzoselenadiazole D-amino acid (FDAA) for imaging bacteria. It is covalently incorporated into peptidoglycans in the cell walls of live bacteria. It also acts as a photosensitizer, bringing about bacterial cell death on exposure to visible light. Se-NADA is effective against both Gram-positive and Gram-negative bacteria. Ex/Em = 470/590 nm.Scientific Data Images for Se-NADA
Application of Se-NADA in B subtilis bacteria cells.
Fluorescence microscopy image of B subtilis bacterial cells treated with SeNADA (250 μM, red) proving incorporation of the D-amino acid into the peptidoglycans of the cell wall. Image kindly provided by Dr Erkin Kuru, Department of Genetics, Harvard Medical School, Boston.Licensing Information
Sold under license from the University of EdinburghOptical Data
| Emission Color | Orange |
| λabs | 470 nm |
| λem | 590 nm |
| Cell Permeable | Yes |
| Application | Fluorescence Microscopy |
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Product Specifications
Molecular Weight
366.62
Formula
C9H9N5O4Se.HCl
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
3-((7-Nitro-2,1,3-benzoselenadiazol-4-yl)amino)-D-alanine hydrochloride
CAS Number
2571574-70-2
InChI Key
NGEWTJCJCRCRQS-PGMHMLKASA-N
SMILES
N[C@@H](C(O)=O)CNC1=CC=C(N(=O)=O)C2=N[Se]N=C12.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.67 | 10 |
Preparing Stock Solutions
for Se-NADA
The following data is based on the product molecular weight 366.62
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.28 mL | 136.38 mL | 272.76 mL |
| 0.5 mM | 5.46 mL | 27.28 mL | 54.55 mL |
| 1 mM | 2.73 mL | 13.64 mL | 27.28 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
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Background References
References are publications that support the biological activity of the product.
- Benson Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo. Nat Commun 2021 PMID: 33888691
Product Specific Notices for Se-NADA
For research use only
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