R-BC154
Tocris Bioscience, part of Bio-Techne | Catalog # 6048
High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs
Discontinued Product
6048 has been discontinued.
View all Integrin Receptor Inhibitors products.
Key Product Details
Description
High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs
Product Description
R-BC154 is a high affinity fluorescent α4β1/α9β1 inhibitor (Kd values are 12.7 and 38 nM, respectively); fluorescent version of BOP (Cat.No. 6047). Rapidly and preferentially mobilizes HSCs and progenitors in vivo. Excitation maximum, 561 nm; emissiosn maximum, 585 nm.Spectra Viewer
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Product Specifications
Molecular Weight
1212.37
Formula
C55H61N9O13S3.CH3CO2H
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
(4R)-4-[4-[[[[4-[3,6-Bis(diethylamino)xanthylium-9-yl]-3-sulfophenyl]sulfonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1-(phenylsulfonyl)-L-prolyl-O-(1-pyrrolidinyl)-L-tyrosine acetate
PubChem ID
131648245
InChI Key
HZQNIDGYMDDNNP-MOVBADFXSA-N
SMILES
CCN(C1=CC2=[O+]C3=C(C(C4=C(S([O-])(=O)=O)C=C(S(=O)(NCC5=CN([C@@H]6C[C@@H](C(N[C@H](C(O)=O)CC7=CC=C(C=C7)OC(N8CCCC8)=O)=O)N(S(=O)(C9=CC=CC=C9)=O)C6)N=N5)=O)C=C4)=C2C=C1)C=CC(N(CC)CC)=C3)CC.CC(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.06 | 5 |
Preparing Stock Solutions
for R-BC154
The following data is based on the product molecular weight 1212.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 16.50 mL | 82.48 mL | 164.97 mL |
| 0.25 mM | 3.30 mL | 16.50 mL | 32.99 mL |
| 0.5 mM | 1.65 mL | 8.25 mL | 16.50 mL |
| 2.5 mM | 0.33 mL | 1.65 mL | 3.30 mL |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Cao Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 2016 PMID: 26975966
- Cao Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org.Biomol.Chem. 2014 PMID: 24363056
Product Specific Notices for R-BC154
For research use only
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